Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

J Bigot, L Guillot, J Guitard, M Ruffin, H Corvol… - Frontiers in …, 2020 - frontiersin.org
… lectin, a fucose-binding lectin expressed on their surface (30, … binding both to the airway
mucins produced by the epithelial … lysosomal protein (Lysosomal-associated membrane protein

Phagolysosomal Survival Enables Non-lytic Hyphal Escape and Ramification Through Lung Epithelium During Aspergillus fumigatus Infection

C Seidel, SD Moreno-Velásquez… - Frontiers in …, 2020 - frontiersin.org
fumigatus either expressing GFP or RFP cytosolic proteins for 4 h. Monolayers were then …
fumigatus spores has been reported on alveolar, bronchial and primary lung epithelial cells in …

Protective role of CFTR during fungal infection of cystic fibrosis bronchial epithelial cells with Aspergillus fumigatus

B Illek, H Fischer, TE Machen, G Hari… - Frontiers in Cellular …, 2023 - frontiersin.org
… Non-specific binding was blocked by treatment with 1% bovine … fumigatus typically enters
bronchioles as asexual spores … CFTR protein in CF bronchial epithelial cells homozygous for …

Aspergillus fumigatus—Host Interactions Mediating Airway Wall Remodelling in Asthma

S Namvar, B Labram, J Rowley, S Herrick - Journal of Fungi, 2022 - mdpi.com
fumigatus also showed superior binding compared with less … fumigatus culture filtrates,
which are devoid of live spores or … damage the integrity of bronchial epithelial cells grown at an …

Differential Proinflammatory Responses to Aspergillus fumigatus by Airway Epithelial Cells In Vitro Are Protease Dependent

J Rowley, S Namvar, S Gago, B Labram, P Bowyer… - Journal of Fungi, 2021 - mdpi.com
fumigatus isolates. Airway epithelial cells were exposed to conidia from a low or high …
fumigatus, and IL-6 and IL-8 gene expression and protein production were quantified. The role of …

Aspergillus fumigatus drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis

UJ Okaa, M Bertuzzi, R Fortune-Grant… - Infection and …, 2023 - Am Soc Microbiol
binding of eight host transcription factors, and expression of nine host response … spore to
hyphal morphological transition of A. fumigatus exposes epithelial cells to a wide range of cell

Respiratory epithelial cells: more than just a physical barrier to fungal infections

BCSC Barros, BR Almeida, DTL Barros, MS Toledo… - Journal of Fungi, 2022 - mdpi.com
… , avidly bind to purified lung mucins. Some proteins that participate in epithelial cellcell
indicated that fungal spores can be absorbed by respiratory epithelial cells efficiently and …

Distinct Cohorts of Aspergillus fumigatus Transcription Factors Are Required for Epithelial Damage Occurring via Contact- or Soluble Effector-Mediated Mechanisms

S Rahman, N van Rhijn, P Papastamoulis… - Frontiers in cellular …, 2022 - frontiersin.org
… assessing epithelial cell detachment and epithelial cell lysis were … fumigatus spores with the
respiratory epithelium can … Calcofluor white (CFW) that binds to chitin and interferes with the …

Stimulation of surfactant exocytosis in primary alveolar type II cells by A. fumigatus

N Schiefermeier-Mach, S Perkhofer, L Heinrich… - Medical …, 2021 - academic.oup.com
… is an opportunistic fungal pathogen with small airborne spores … with lung epithelial cells. For
this purpose, we infected AT II … -cell interactions, including reversible attachment and binding

The complement system in Aspergillus fumigatus infections and its crosstalk with pentraxins

R Parente, A Doni, B Bottazzi, C Garlanda… - FEBS …, 2020 - Wiley Online Library
… Indeed, most of the inhaled spores are mechanically removed … epithelial cells (mostly type
II pneumocytes) in cooperation with … proteins have been described up to now that bind the α-…