… TEM analysis revealed that Chrm1 loss led to mitochondrial ultrastructural defects and
alteration in the tinctorial properties of cortical neurons causing a significant increase in the …

… , comparative analysis of diseased and unaffected human brain … It was proposed that structural
alterations in cholinergic … above-mentioned important biological question by analyzing the …

… acetylcholine receptors (mAChRs), present in both the … the receptor and aim to regulate
the ensuing biological response. … , will be accompanied by modifications in the functional and …

… cortical brain slice model, we find that postsynaptic muscarinic acetylcholine receptor function
… for mAChR function and disease modification in moderate stages of Alzheimer’s disease. …

… This evidence has contributed to highlight new roles for acetylcholine in various biological …
different missense mutations causing an altered function of this receptor have been identified. …

… These ligands provide a means to fine-tune the biological … Muscarinic acetylcholine receptors
(mAChRs), particularly … dependent conformational changes in the receptor transmembrane …

… Here, we review and summarize the essential characteristics and current findings concerning
α7nAChRs in four common brain diseases (AD, Parkinson’s disease, schizophrenia, and …

… human brain tissues, we demonstrated that loss of Cholinergic Receptor Muscarinic 1 (…
hippocampal mitochondrial characteristics is necessary to fully understand our retrospective …

… These changes, together with validation of the role of ACh and cholinergic receptors in …
complement activation, thereby unravelling the biochemical changes that underpin the disease-…

… Muscarinic acetylcholine receptors play a significant role in modulating physiological …
cholinergic hypothesis is characterized by alterations in the biochemical state of the brain …