… , and promote the reconstruction of cancer cell bioenergetics and biogenesis, leading to the
… maintain homeostasis under normal conditions and promote adaptation to a variety of stress …

… With respect to intrinsic bioenergetic remodeling, in-depth bioenergetic analysis of
chemoresistant mitochondria revealed adaptations in favor of increased respiratory CI function. Such …

… types suggested an active participation of mitochondria in chemoresistance (17). Therefore,
… signaling in ovarian cancer cells. To test this hypothesis, we compared the bioenergetics of …

… Bioenergetic adaptation is also a mechanism for cancer cells to cope with drug challenges.
The cisplatin sensitive ovarian cancer cells have active glycolysis. However, their cisplatin …

… Cancer cells usually show adaptations to their metabolism … contribute to chemoresistance
after a period of treatment for EOC… indicated by a higher BioEnergetic Cellular index and a non-…

… regulation of the metabolic adaptations of cancer cells and the … cancer cell types may undergo
different bioenergetic … -derived ovarian cancer cell lines revealed that chemosensitive cells …

… bioenergetic profiles of ovarian cancer cell lines overexpressing SDHA vs. their respective
SDHA-low counterparts. The cell lines showed a substantial diversity in their bioenergetic … cell …

… providing an adaptation to metabolic changes, preserving cell integrity, and … In fact, bioenergetic
analyses defined two molecular … cells, and this does not occur in chemoresistant ovarian …

… comparing ovarian cancer cells and CSCs. In addition, malignant niches are formed by
cancer cells … , the metabolic plasticity of ovarian cancer cells, adaptation to the dynamic tumor …

… among ovarian cancers with a 5-year overall survival (OS) of 35% [1,4,5]. Standard treatment
… Different studies reported metabolic adaptation in cancer cells after a specific treatment, …