Microbial production of riboflavin: biotechnological advances and perspectives

J You, X Pan, C Yang, Y Du, T Osire, T Yang… - Metabolic …, 2021 - Elsevier
… in biotechnology have led to a complete shift in the commercial production of riboflavin from
… we provide a comprehensive review of biotechnologies that enhance riboflavin production in …

Production of riboflavin and related cofactors by biotechnological processes

S Liu, W Hu, Z Wang, T Chen - Microbial cell factories, 2020 - Springer
… Modern commercial production of riboflavin is based on … The biotechnological processes
for the production of RF and … This review covers the recently developed biotechnological

[HTML][HTML] Biotechnological strategies of riboflavin biosynthesis in microbes

JR Zhang, YY Ge, PH Liu, DT Wu, HY Liu, HB Li… - Engineering, 2022 - Elsevier
… and the development of riboflavin-overproducing strains via chemical … riboflavin biosynthesis
and can promote the research and development of fermented food products rich in riboflavin

[HTML][HTML] Production of vitamin B2 (riboflavin) by microorganisms: an overview

LA Averianova, LA Balabanova, OM Son… - … and Biotechnology, 2020 - frontiersin.org
… of riboflavin has been its global use as an animal and human nutritional supplement. Being
well-informed of the latest research on riboflavin … strains using biotechnology and metabolic …

Strategies to increase the production of biosynthetic riboflavin

G Zhao, F Dong, X Lao, H Zheng - Molecular Biotechnology, 2021 - Springer
… for producing riboflavin. At present, there are three types of strains used in industrial riboflavin
production: … This article briefly introduces recent progress in the fermentation of riboflavin. …

Increased Production of Riboflavin by Coordinated Expression of Multiple Genes in Operons in Bacillus subtilis

J You, Y Du, X Pan, X Zhang, T Yang… - … Synthetic Biology, 2022 - ACS Publications
… This study describes a strategy to improve riboflavin production by generating libraries of
tunable intergenic regions (TIGRs) to tune the expression of key riboflavin synthesis genes in …

Rational Engineering of Escherichia coli for High-Level Production of Riboflavin

S Liu, W Hu, Z Wang, T Chen - Journal of Agricultural and Food …, 2021 - ACS Publications
… Moreover, the riboflavin titer of LS72T reached 21 g/L in fed-batch cultivation, with a yield of
110 mg riboflavin/g glucose. To our knowledge, both the riboflavin titer and yield obtained in …

Improving the Production of Riboflavin by Introducing a Mutant Ribulose 5-Phosphate 3-Epimerase Gene in Bacillus subtilis

B Yang, Y Sun, S Fu, M Xia, Y Su, C Liu… - … and Biotechnology, 2021 - frontiersin.org
… enhance riboflavin production. This work exemplifies a strategy for improving the riboflavin
… reference for detecting potential bottlenecks in riboflavin biosynthesis in rpe mutant strains. …

Metabolic engineering of Bacillus subtilis for enhancing riboflavin production by alleviating dissolved oxygen limitation

J You, C Yang, X Pan, M Hu, Y Du, T Osire, T Yang… - Bioresource …, 2021 - Elsevier
… In recent years, the microbial fermentation of riboflavin, an example of a white biotechnology,
has completely replaced the chemical synthesis of the vitamin in industry, with the main …

Engineering of Synechococcus sp. strain PCC 7002 for the photoautotrophic production of light-sensitive riboflavin (vitamin B2)

B Kachel, M Mack - Metabolic Engineering, 2020 - Elsevier
biotechnological processes mostly based on the filamentous fungus Ashbya gossypii (a …
riboflavin overproducer) and the gram-positive bacterium Bacillus subtilis. In 2015, the riboflavin