Prevention and treatment of bleeding with direct oral anticoagulants

RM Crawley, RL Anderson - Drugs, 2020 - Springer
… supports lower bleeding risks with dabigatran over warfarin, … of bleeding risk reduction
with rivaroxaban compared with … Low-dose therapy is also recommended for apixaban doses …

Effect of non‐recommended doses versus recommended doses of direct oral anticoagulants in atrial fibrillation patients: A meta‐analysis

X Liu, M Huang, C Ye, X Xiao, C Yan - Clinical Cardiology, 2021 - Wiley Online Library
dabigatran, rivaroxaban, apixaban, edoxaban) are at least non-inferior in reducing the risks
of stroke and bleeding compared with warfarin. … of (1) low dose of dabigatran (110 mg twice a …

Effectiveness and safety of non-vitamin K antagonist oral anticoagulants and warfarin in atrial fibrillation: a Scandinavian population-based cohort study

S Halvorsen, SP Johnsen, M Madsen… - … Journal-Quality of …, 2022 - academic.oup.com
bleeding were lower with apixaban and dabigatran and higher with rivaroxaban, each compared
with warfarin… ≥18 years initiating apixaban, rivaroxaban, dabigatran, or warfarin from 1 …

Risks of post-colonoscopic polypectomy bleeding and thromboembolism with warfarin and direct oral anticoagulants: a population-based analysis

LHS Lau, CLT Guo, TCF Yip, JWY Mak, SH Wong… - Gut, 2022 - gut.bmj.com
… (apixaban, dabigatran, edoxaban, rivaroxaban or warfarin) by their … their corresponding
thrombotic and bleeding risks.25 26 … Low-dose rivaroxaban (<20 mg daily) was associated with a …

Treatment of adults with intracranial hemorrhage on apixaban or rivaroxaban with prothrombin complex concentrate products

R Castillo, A Chan, S Atallah, K Derry, M Baje… - Journal of thrombosis …, 2021 - Springer
… 15 for both aPCC and low-dose 4F-PCC and a GCS of 14 for high-dose 4F-PCC. The median
ICH score for patients with a spontaneous IPH was 1 in aPCC, 2 in low-dose 4F-PCC and …

Systematic review and meta-analysis of direct oral anticoagulants versus warfarin in atrial fibrillation with low stroke risk

KY Fong, YH Chan, C Yeo, GYH Lip, VH Tan - The American Journal of …, 2023 - Elsevier
bleeding risks with apixaban and dabigatran compared with warfarin, but not for rivaroxaban
Several studies combined results from both standard-dose DOAC and low-dose DOAC, …

Dose specific effectiveness and safety of DOACs in patients with non-valvular atrial fibrillation: A Canadian retrospective cohort study

E Rahme, R Godin, H Nedjar, K Dasgupta… - Thrombosis …, 2021 - Elsevier
… We compared stroke, bleeding, and mortality rates on and off therapy for standard and
low-dose DOACs (apixaban, rivaroxaban, dabigatran) versus warfarin in a Canadian cohort. We …

Real-world safety and efficacy of direct oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of 605 771 patients

D Menichelli, F Del Sole, A Di Rocco… - European Heart …, 2021 - academic.oup.com
… that Apixaban was associated with lower risk of major and GI … bleeding, we found a similar
performance of Dabigatran with … number of events according to high and low dose of DOACs. …

Characteristics and outcomes in patients with atrial fibrillation receiving direct oral anticoagulants in off-label doses

A Briasoulis, Y Gao, C Inampudi, P Alvarez… - BMC cardiovascular …, 2020 - Springer
… of low dose or standard dose and the risk of any bleedingdabigatran, rivaroxaban or apixaban
with renal indication for … who qualify for low dose rivaroxaban and dabigatran if decisions …

Gastrointestinal bleeding on oral anticoagulation: what is currently known

AB Ingason, JP Hreinsson, ES Björnsson - Drug Safety, 2022 - Springer
warfarin, GIB rates were similar between warfarin users and both apixaban and low-dose
dabigatran … The higher GIB risk of rivaroxaban compared to apixaban and dabigatran may be …