… In this review article, we will briefly discuss the relationships between metabolic rate and
longevity, the impact of various anti-aging interventions on energy metabolism, and the current …

… condition, and thus translate into longevity and reproductive intensity (Fig. 3B). Section III
organizes the enormous diversity of life histories around the mutual role of mortality and MR. …

… metabolic rate (per body weight per day) and lifespan (R 2 … for the effect of CR on energy
metabolism including resting EE, … CR reduces metabolic rate. First, changes in composition of …

… lifespan in C57BL/6JOlaHsd mice in both sexes. Overexpression of SIRT6 reduced the
age-related metabolic decline in energy metabolism … for maintaining energy metabolism and …

… In this review, we discuss the pro-longevity effects of targeting metabolic pathways in specific
tissues and how these interventions communicate with distal cells to modulate aging. …

… As a consequence, energy metabolism seems to change throughout the lifespan with
glucose catabolite fluxes being redistributed with advanced age between glycolysis and PPP, in …

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical
… and aging and should help shape nutrition and health strategies across the life span. …

… of lifespan extension by GH suppression from its dwarfism (small body size caused by GH
suppression), opening an important possibility that CR may extend lifespan without the cost of …

… In general, women live longer than men, and life expectancy is increasing worldwide. The
… Each form has a unique function that matches a woman’s life cycle characteristics, such as …

… to body size. Therefore, a first step in comparative studies frequently involves correcting for
effects of body size … However, commonly used traditional methods for making these body-size …