Population analysis of Staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia

…, N Park, DE Heinrichs, L Benedictus, T Connelley… - Mbio, 2020 - Am Soc Microbiol
… (SAgs) are a family of secreted toxins that stimulate T cell … As cattle contain high levels of
γδ T cells in peripheral blood, … , suggesting that it has not evolved to stimulate bovine T cells. …

[HTML][HTML] Relative virulence of Staphylococcus aureus bovine mastitis strains representing the main Canadian spa types and clonal complexes as determined using in …

…, A Larose, C Ster, JF Lucier, S Rodrigue, S Park… - Journal of Dairy …, 2021 - Elsevier
… both clinical and subclinical bovine mastitis in dairy cattle. Prediction of disease … superantigens
(SAg) which, when expressed by the bacterium, may stimulate one or more T lymphocyte

Identification and phenotype of MAIT cells in cattle and their response to bacterial infections

MD Edmans, TK Connelley, S Jayaraman… - Frontiers in …, 2021 - frontiersin.org
Cattle MAIT cells were responsive to stimulation by 5-OP-RU … strain DH5α and Staphylococcus
aureus strain RF122 from … + T cells and 5-OP-RU reactive cells in cattle peripheral blood…

Staphylococcus aureus isolated from skin from atopic-dermatitis patients produces Staphylococcal enterotoxin Y, which predominantly induces T-cell receptor Vα …

F Aziz, J Hisatsune, L Yu, J Kajimura… - Infection and …, 2020 - Am Soc Microbiol
… Concurrently, the same ORF was identified in a bovine isolate of S. … Overall, we demonstrate
that SEY 2 acts as a superantigen that specifically stimulates human T cells bearing TCR Vα …

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

B Campos, AC Pickering, LS Rocha, AP Aguilar… - BMC Veterinary …, 2022 - Springer
Staphylococcal superantigens activate T-cells resulting in the … isolates of dairy cattle across
all investigated countries with … As a result, several T cells that share the same Vβ segment …

Immunoproteomic analysis of the secretome of bovine-adapted strains of Staphylococcus aureus demonstrates a strain-specific humoral response

SD Drumm, P Cormican, P O'Boyle, RA Owens… - Veterinary Immunology …, 2022 - Elsevier
repertoire of superantigens (SAg) and staphylococcal … on the subsequent immune responses
of cattle, and how this … to identify antigenic proteins that stimulate a local mucosal response …

Differential immune response to two Staphylococcus aureus strains with distinct adaptation genotypes after experimental intramammary infection of dairy cows

…, C Baravalle, CM Camussone, S Monecke… - Microbial …, 2022 - Elsevier
… a further immune response, mainly stimulated by strain P and … vitro studies with MAC-T
cells and bovine macrophages [16]. The … experimental IMI studies in cattle in which different S. …

Evaluation of the Efficacy of a Cholera Toxin-Based Staphylococcus aureus Vaccine against Bovine Intramammary Challenge

HA Alabdullah, E Overgaard, D Scarbrough… - Vaccines, 2020 - mdpi.com
aureus vaccination in cattle include whole-cell live and killed … doses this vaccine was found
to stimulate significant S. … aureus superantigens (SAgs) can activate specific T-cell subsets, …

[HTML][HTML] … and immune characteristics in first-lactation Holstein-Friesian cows following intramammary infection with genotypically distinct Staphylococcus aureus …

DA Niedziela, MP Murphy, J Grant, OM Keane… - Journal of dairy …, 2020 - Elsevier
Staphylococcus aureus was recovered from milk of all … This is the first in vivo study in cattle
that confirms that 2 Staphstimulates production of cytokines and chemokines by the epithelial …

Immunoproteomic analysis of the serum IgG response to cell wall-associated proteins of Staphylococcus aureus strains belonging to CC97 and CC151

SD Drumm, P Cormican, RA Owens, J Mitchell… - Veterinary …, 2023 - Springer
Staphylococcus aureus lineages associated with bovine … approach was used to identify the
repertoire of, and interrogate the … All cows in this group also had a reactive band at ~50 kDa. …