… the BBB, which they penetrate to enter the brain directly (via transcellular … Cryptococcus
crosses the blood-brain barrier (BBB). Cryptococci use host inositol which binds to their inositol …

… novel disease control strategies. Our recent studies revealed that inositol utilization by the
fungus promotes … ability to penetrate across the blood-brain barrier (BBB), suggesting a role for …

… neoformans migrates to the brain across the blood–brain … , the brain has high levels of the
sugar inositol, and inositol … , cryptococcal urease is a major virulence factor and promotes …

… probably help identify novel immunomodulating therapeutics … from the brain parenchyma by
the blood–brain barrier (BBB); … An inositol-dependent Cryptococcus traversal of the BBB has …

… tissues, and the blood-brain barrier; and finally, (vi) proliferation … regulated genes that are
both novel and previously identified, … in inositol, a known stimulator for promoting Cryptococcus …

… of Cryptococcus neoformans—the most common pathogen causing fungal meningitis—and
its ability to penetrate … On the basis of these previous findings, we hypothesized that inositol …

… ) in blood-brain barrier (BBB) crossing and brain infection in … involved in brain infection,
including inositol transporters, a … promote BBB crossing and survival/proliferation in the brain …

… Cryptococcal fungal cells have a predilection for the brain and they are capable of traversing
the blood brain barrier and invade the brain … The advantage of this novel model is the ability …

… to the brain, where it may cross the blood-brain barrier and cause … promotes cryptococcal
survival and proliferation. … nutrient acquisition in the inositol-rich brain environment. Compared …

… the natural route of infection (lung–blood–brain). Thus, it is … an insulin syringe with a cuff to
prevent penetration > 1 mm. A midline … of genes related to inositol metabolism after 10 days of …