… response is situated within the brainstem and is also crucial … anatomy and function of the
brainstem pain-modulation circuitry, … have begun to explore brainstem pain-modulation circuitry …

… Nociceptive projection neurons are mostly located in lamina I and relay sensory information
to the brain stem and the thalamus. A subpopulation of these neurons expresses the …

… blockade of spinal α 1 -ARs 49 suppresses PNI-induced mechanical hypersensitivity and
that PNI changes neither the spontaneous activity of LC neurons 50 nor the spinal NE content …

… in spinal-PAG projection neurons at a holding potential of −70 mV by stimulation of the dorsal
root. Spinal-PAG projection neurons … In spinal-PAG projection neurons of wild-type mice, a …

… a single target location or neuron, is a hallmark of back pain transmission. Lumbar C- and
Aδ nociceptive nerve fibers arising from nerve roots of multiple spinal segments may converge …

… of spinal dorsal horn neurons, particularly WDR neurons, … in pain transmission, such as the
cortex, PAG, and in the spinal … systems originating in the brainstem play an essential role in …

… , although it is still urgent to understand how OFF cells and 5-HTergic neurons modulate
spinal pain transmission and how these RVM neurons cooperate in different pain states. …

… In conclusion, spinal ENKergic neurons receive direct excitatory inputs from primary afferents,
which might be directly recruited to release ENK under the condition of noxious stimuli; …

… This represents activity in a population of spinal neurons that responded more strongly to
noxious thermal stimulation. This Spinalnoci cluster was somatotopically localised, given that …

… It is composed of (1) peripheral sensory neurons that sense … system (pain transmission
pathways); (3) sets of neurons that … nerve ganglia outside the spinal cord or brainstem. The stimuli …