Cell envelope proteases and peptidases of Pseudomonas aeruginosa: multiple roles, multiple mechanisms

A Heywood, IL Lamont - FEMS Microbiology Reviews, 2020 - academic.oup.com
… signal peptide that directs protein export through the cytoplasmic membrane and … bacteria,
prelipoproteins are usually transported through the cytoplasmic membrane via the Sec system

Dynamics of co-translational membrane protein integration and translocation via the Sec translocon

MJM Niesen, MH Zimmer… - Journal of the American …, 2020 - ACS Publications
across the cell membrane via the Sec translocon is required for the export of many secretory
proteins, as … ER membrane or SecYEG in bacteria. Extracytoplasmic loops and secretory …

Surveying membrane landscapes: a new look at the bacterial cell surface

T Lithgow, CJ Stubenrauch, MPH Stumpf - Nature Reviews Microbiology, 2023 - nature.com
… imaging (Box 2) can break the classic diffraction limit that … proteins such as OmpF are
translated on ribosomes distributed throughout the cytoplasm and then randomly encounter Sec

Type IV secretion systems: advances in structure, function, and activation

TRD Costa, L Harb, P Khara, L Zeng, B Hu… - Molecular …, 2021 - Wiley Online Library
… A few other T4SSs export DNA or proteins to the milieu, or … in Gram-positive bacteria or
obligate intracellular pathogens, … the channel–pilus junction causes breakage of the mature F …

[HTML][HTML] Bacteriophage-encoded enzymes destroying bacterial cell membranes and walls, and their potential use as antimicrobial agents

Ł Grabowski, K Łepek, M Stasiłojć… - Microbiological …, 2021 - Elsevier
… therapies is crucial for efficient treatment of bacterial infections in the near future. One … of
bacterial cell membranes and walls. Bacteriophages use such enzymes to destroy bacterial host …

CryoEM of bacterial secretion systems: A primer for microbiologists

TR Umrekar, E Cohen, T Drobnič… - Molecular …, 2021 - Wiley Online Library
… , inelastically scattered electrons break covalent bonds and … their tip with subunits exported
through a central channel by … secreted into the periplasm by the Sec secretion system and …

Human guanylate binding proteins: nanomachines orchestrating host defense

M Kutsch, J Coers - The FEBS journal, 2021 - Wiley Online Library
… (SEC) to assign the molecular weight to a protein complex based on its hydrodynamic radius.
However, DLS and SEC … the insertion of polymers into the bacterial cell wall is dependent …

Structure of the mycobacterial ESX-5 type VII secretion system pore complex

KSH Beckham, C Ritter, G Chojnowski… - Science …, 2021 - science.org
… Moreover, our structure showed an unanticipated break in symmetry … example, a highly
conserved Met-Met-Met loop of the export … of bacterial secretion machineries that evolved through

Identification and Characterization of a New Type of Holin-Endolysin Lysis Cassette in Acidovorax oryzae Phage AP1

M Zhang, Y Wang, J Chen, X Hong, X Xu, Z Wu… - Viruses, 2022 - mdpi.com
system to facilitate its translocation into the periplasm [9] However, endolysins are exported
in Gram-negative bacteria by … the involvement of the Sec system during LysAP production (…

[HTML][HTML] How do chaperones bind (partly) unfolded client proteins?

I Sučec, B Bersch, P Schanda - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
… , membrane proteins destined to the bacterial outer membrane … weak and require less energy
to break them than the energy … of these proteins are recognized and transported to the Sec