… immunotherapies aim at breaking immune tolerance to tumour-… cells may be modified
by EVs to generate split tolerance, as … Similarly, costimulatory molecules on antigen-presenting …

… Exposure to tumor necrosis factor (TNF) can also exert a similar type of tolerance on …
Such cross-tolerance appears to be induced via overlapping molecular mechanisms. TNF-…

… Because antigen-presenting cells are tolerogenic when they … may induce antigen-specific
tolerance. Here, we show that, in … 1a) to antigenic peptides and small molecules modified with …

… a heterogeneous population of antigen presenting cells, play … “modified self” antigens
supports the hypothesis that a “break… tolerance through the expression of co-inhibitory molecules …

… initiated by the presentation of modified gluten on APCs (120). … have demonstrated that
breaking oral tolerance to food … -associated molecular patterns (DAMPs) are self-molecules …

… specific immune tolerance, as trained antigen presenting cells… , small molecule drug, and
autoantigens mediated tolerance … help to break through some limitations of oral tolerance in …

… the antigen presenting and tolerogenic properties of these … , can effectively break the T
cell tolerance and treat many … deleted of costimulatory molecules or ectopically expressing …

… This technology has been shown to improve antigen presenting … platforms affect the immune
response at the molecular level. … The ability to break self-tolerance has facilitated the use of …

… Modifying the recipient’s antigen- presenting cells which … Transplantation has been one of
the most ground breaking … , where allogeneic intact MHC molecules are acquired by recipient …

… A, Antigen presenting cells (APCs) express MHC-II molecules complexed with linear
peptide fragments in antigen-binding pockets. CD4 + T cells bear αβ TCRs with the capacity to …