Molecular mechanisms, biomarkers and emerging therapies for chemotherapy resistant TNBC

P Ferrari, C Scatena, M Ghilli, I Bargagna… - … journal of molecular …, 2022 - mdpi.com
therapies allow to select specific antiblastics that alone or by integrating the conventional
therapeutic approach … SERPINE1 in PTX drug resistance of breast cancer and appointed it as a …

Resistance and overcoming resistance in breast cancer

A Luque-Bolivar, E Pérez-Mora… - Breast Cancer …, 2020 - Taylor & Francis
… prognosis and achieving a better response to therapy. This review focuses on recent studies
on the biological and molecular mechanisms of response and resistance to treatment in BC. …

[HTML][HTML] Mechanisms of endocrine therapy resistance in breast cancer

F Rasha, M Sharma, K Pruitt - Molecular and cellular endocrinology, 2021 - Elsevier
… lead to inefficiency of endocrine therapy. In this section of the review, we will discuss some
of the molecular mechanisms that may be determinants of endocrine therapy resistance. …

Epigenetic mechanisms in breast cancer therapy and resistance

L Garcia-Martinez, Y Zhang, Y Nakata, HL Chan… - Nature …, 2021 - nature.com
breast cancers express the estrogen receptor (ERα) and agents targeting this pathway represent
the main treatment … of hormone-responsive breast cancer since its early adoption in the …

Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches

TB Emran, A Shahriar, AR Mahmud, T Rahman… - Frontiers in …, 2022 - frontiersin.org
mechanisms in cancer cells and discusses ongoing laboratory approaches and novel
therapeutic … in various cancer types. In this review, we discuss both intrinsic and acquired drug …

[HTML][HTML] EMT mechanism in breast cancer metastasis and drug resistance: Revisiting molecular interactions and biological functions

M Hashemi, HZ Arani, S Orouei, S Fallah… - Biomedicine & …, 2022 - Elsevier
… associations and therapeutic approaches in near future. … -resistance in breast cancer via
activation of Akt signaling. Silencing prevents radio-resistance and decreases invasion of breast

Molecular mechanisms of endocrine resistance in estrogen-receptor-positive breast cancer

EB Belachew, DT Sewasew - Frontiers in endocrinology, 2021 - frontiersin.org
… indicates that a combination of endocrine therapy with other drugs that target different
molecular pathways and coregulators will be one of the most promising treatment approaches. …

Non-genetic mechanisms of therapeutic resistance in cancer

JC Marine, SJ Dawson, MA Dawson - Nature Reviews Cancer, 2020 - nature.com
… of the molecular mechanisms underlying drug adaptation … to endocrine resistance in breast
cancer through upregulation of … Understandably, before such novel therapeutic approaches

Activation of PI3K/AKT/mTOR pathway causes drug resistance in breast cancer

C Dong, J Wu, Y Chen, J Nie, C Chen - Frontiers in pharmacology, 2021 - frontiersin.org
underlying mechanisms of chemoresistance in breast cancerresistance are attributed to
diverse molecular mechanisms, … -apoptosis, autophagy, and other mechanisms (Ji et al., 2019). …

Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies

A Marra, D Trapani, G Viale, C Criscitiello… - … breast cancer, 2020 - nature.com
… Triple-negative breast cancer (TNBC) is not a unique disease, encompassing multiple …
the implementation of biomarker-driven therapeutic approaches. However, biomarker-based …