Identifying transcription factor dysregulation in RUNX1-ETO leukaemia
A Azevedo - 2022 - orca.cardiff.ac.uk
… for binding to the promotors of several target genes, such as E-cadherin, as well as cooperating
in transcriptional … RUNX1-ETO significantly downregulated the expression of C/EBPβ …
in transcriptional … RUNX1-ETO significantly downregulated the expression of C/EBPβ …
Tgfβ1 suppressed matrix mineralization of osteoblasts differentiation by regulating SMURF1–C/EBPβ–DKK1 axis
B Nam, H Park, YL Lee, Y Oh, J Park, SY Kim… - International Journal of …, 2020 - mdpi.com
… /enhancer-binding protein beta (C/EBPβ) were dramatically … As expected, the protein levels
of C/EBPβ, DKK1, RUNX2, … The induction of SMURF1 promoter by TGFβ1 treatment also …
of C/EBPβ, DKK1, RUNX2, … The induction of SMURF1 promoter by TGFβ1 treatment also …
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration
… Local administration of DEL-1 or of its N-terminal segment containing the integrin-binding …
genes such as the master transcription factor Runt-related transcription factor-2 (Runx2) and …
genes such as the master transcription factor Runt-related transcription factor-2 (Runx2) and …
A RUNX–CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes
K Murakami, H Sasaki, A Nishiyama, D Kurotaki… - Nature …, 2021 - nature.com
… shown that gene transcription is facilitated by promoter-distal … landscape around the Irf8
gene in relevant myeloid cell … RUNX1 and RUNX2 were previously found to bind to the +56 …
gene in relevant myeloid cell … RUNX1 and RUNX2 were previously found to bind to the +56 …
Waiting in the wings: RUNX3 reveals hidden depths of immune regulation with potential implications for inflammatory bowel disease
E Dybska, AT Adams, R Duclaux‐Loras… - Scandinavian …, 2021 - Wiley Online Library
… hallmarks, including two promoter regions (P1 and P2), large … RUNX1 and RUNX2 are
essential for organogenesis. … of the IBD-associated transcription factors with the same binding site …
essential for organogenesis. … of the IBD-associated transcription factors with the same binding site …
Gene regulatory landscape in osteoblast differentiation
H Hojo, S Ohba - Bone, 2020 - Elsevier
… Since Runx2 and C/EBPβ form a transcriptional complex and … genes were accompanied by
the binding of Runx2, C/EBPβ, … H3K4me3 at the P1 promoter to promote Runx2 expression […
the binding of Runx2, C/EBPβ, … H3K4me3 at the P1 promoter to promote Runx2 expression […
Differentiation of osteoblasts: the links between essential transcription factors
… transcription activator of Runx2 by binding to the P1 promoter, which is the transcriptional
regulator of the Runx2-II … C/EBPβ is expressed in osteoblastic cells, and its regulation becomes …
regulator of the Runx2-II … C/EBPβ is expressed in osteoblastic cells, and its regulation becomes …
Species-specific deployment of Runx2 isoforms and differential regulation of target genes during avian jaw development and evolution
SS Smith, DB Chu, T Qu, T Huang, AJ Lucena, G Krish… - bioRxiv, 2021 - biorxiv.org
… gene is Runx2, which is a transcription factor required for osteoblast differentiation. RUNX2
protein binds many target genes … P1 and P2 promoters as well as the QA repeat in the duck …
protein binds many target genes … P1 and P2 promoters as well as the QA repeat in the duck …
The role of Trithorax family regulating osteogenic and Chondrogenic differentiation in mesenchymal stem cells
Q Ma, C Song, B Yin, Y Shi, L Ye - Cell Proliferation, 2022 - Wiley Online Library
… transcription of Runx2/p57. In addition, MEN1, MLL2, and MLL3 (but not MLL1 or MLL4) bind
to Runx2 P1 promoter, regulating … by CCAAT/enhancer-binding protein β (C/EBPβ) to Bglap …
to Runx2 P1 promoter, regulating … by CCAAT/enhancer-binding protein β (C/EBPβ) to Bglap …
CAGE-seq analysis of osteoblast derived from cleidocranial dysplasia human induced pluripotent stem cells
A Ooki, S Onodera, A Saito, A Oguchi, Y Murakawa… - Bone, 2020 - Elsevier
… binds to the homeodomain response element of distal promoter P1 [49], specifically regulates
type II RUNX2 … study revealed that the P2 promoter of RUNX2 gene is dominantly used in …
type II RUNX2 … study revealed that the P2 promoter of RUNX2 gene is dominantly used in …