Formation and maturation of the phagosome: a key mechanism in innate immunity against intracellular bacterial infection

HJ Lee, Y Woo, TW Hahn, YM Jung, YJ Jung - Microorganisms, 2020 - mdpi.com
Phagosomes then interact with lysosomes to form … on phagosome maturation among the
various immune evasion … phagocytes, including macrophages, neutrophils and dendritic cells. …

Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

EA Gaylord, HL Choy, TL Doering - Pathogens, 2020 - mdpi.com
… neoformans may manipulate phagosome maturation to enhance its own … by macrophages
are degraded in the phagosome, C. neoformans uses at least three mechanisms to escape

[HTML][HTML] Real-time visualization of phagosomal pH manipulation by Cryptococcus neoformans in an immune signal-dependent way

EJ Santiago-Burgos, PV Stuckey… - Frontiers in Cellular …, 2022 - frontiersin.org
interactions driving disease establishment is Cryptococcus’s … or Mycobacteria, escape from
the phagosome before it acidifies; … albicans’s phagosomes acidify faster in M1 macrophages

Cholesterol and sphingomyelin are critical for Fcγ receptor–mediated phagocytosis of Cryptococcus neoformans by macrophages

AM Bryan, JK You, G Li, JH Kim, A Singh… - Journal of Biological …, 2021 - ASBMB
macrophages play a key role in the outcome of a cryptococcal infection, it is crucial to understand
factors that mediate phagocytosis of C… govern macrophages' ability to phagocytose C. …

Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal–macrophage interaction

…, PR Williamson, A Jedlicka, A Casadevall, C Coelho - …, 2022 - academic.oup.com
phagosomes, may simply reflect the large size of the cryptococcal phagosome, and the fact
that C… We found that Yor1 is not involved in manipulating phagolysosomal pH. To assess any …

Host–Pathogen Interactions and Correlated Factors That Are Affected in Replicative-Aged Cryptococcus neoformans

VKA Silva, S Min, K Yoo, BC Fries - Journal of Fungi, 2024 - mdpi.com
… phagolysosomes and can manipulate the phagosome pH. … replicate within the acidic
phagosome and to escape via a non-… interactions with macrophages [15], we hypothesized that C. …

Kicking sleepers out of bed: Macrophages promote reactivation of dormant Cryptococcus neoformans by extracellular vesicle release and non-lytic exocytosis

…, CL Marina, A Sturny-Leclère, C Hoffmann… - PLoS …, 2023 - journals.plos.org
… of BMDM-VBNC cells interactions, we found that intracellular … neoformans can escape the
macrophage phagolysosome by … the ability to manipulate the micronutrient composition of the …

[HTML][HTML] Cryptococcus escapes host immunity: What do we know?

C Yang, Y Huang, Y Zhou, X Zang, H Deng… - Frontiers in Cellular …, 2022 - frontiersin.org
… PAMPs) of Cryptococcus and mediate the formation of phagosomes by … Cryptococcus can
escape from M1 macrophages by … on the interaction between Cryptococcus and host immunity. …

[HTML][HTML] Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection

…, O Dutta, K Wang, A Rivera, C Xue - Frontiers in Cellular …, 2022 - frontiersin.org
… to interact with and manipulate host macrophages. These … This capsule plays the dual role
of “sword” by evading host immune … based on their PAMPs and engulf them into phagosomes. …

Antifungal Peptide SP1 Damages Polysaccharide Capsule of Cryptococcus neoformans and Enhances Phagocytosis of Macrophages

Y Liu, Y Zhang, X Zhao, W Lu, Y Zhong… - Microbiology …, 2023 - Am Soc Microbiol
… killing by macrophages and prevented the immune escape of C. … that SP1 interacts with GXM
in the polysaccharide capsule of C. … reinforces the interaction between SP1 and GXM. This …