Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

EA Gaylord, HL Choy, TL Doering - Pathogens, 2020 - mdpi.com
… neoformans may manipulate phagosome maturation to enhance its own … by macrophages
are degraded in the phagosome, C. neoformans uses at least three mechanisms to escape

Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death

EJ Thak, SB Lee, S Xu-Vanpala, DJ Lee, SY Chung… - MBio, 2020 - Am Soc Microbiol
… Phagocyte escape is crucial for dissemination of C. neoformans … to block phagosome
acidification by staining macrophages … the phagosome by manipulating C. neoformans-containing …

Manipulation of host phagocytosis by fungal pathogens and therapeutic opportunities

LJ Jia, K González, T Orasch, F Schmidt… - Nature …, 2024 - nature.com
… in host phagosome–fungal pathogen interactions, with a … to manipulate phagosome
maturation and to escape from … , actively manipulate the activation state of host macrophages by …

Elements of dissemination in cryptococcosis

JM Bednarek, JCS Brown - mBio, 2024 - journals.asm.org
escape is influenced by several virulence factors specific to C… an insufficient anti-inflammatory
macrophage response, the … phagosome pH has demonstrated that basic phagosomal pH …

Survival in macrophages induces enhanced virulence in Cryptococcus

JA Nielson, AJ Jezewski, M Wellington, JM Davis - Msphere, 2024 - Am Soc Microbiol
Evasion of host immunity is a central theme of Cn … and (b) by altering the cell surface to
manipulate the nature of subsequent … occurs in vivo and is influenced by phagosomal pH. mBio 2:…

Host–Pathogen Interactions and Correlated Factors That Are Affected in Replicative-Aged Cryptococcus neoformans

VKA Silva, S Min, K Yoo, BC Fries - Journal of Fungi, 2024 - mdpi.com
… phagolysosomes and can manipulate the phagosome pH. … replicate within the acidic
phagosome and to escape via a non-… interactions with macrophages [15], we hypothesized that C. …

Macrophage Mediated Immunomodulation During Cryptococcus Pulmonary Infection

…, O Dutta, K Wang, A Rivera, C Xue - Frontiers in Cellular …, 2022 - frontiersin.org
… to interact with and manipulate host macrophages. These … This capsule plays the dual role
of “sword” by evading host immune … based on their PAMPs and engulf them into phagosomes. …

Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?

PV Stuckey, FH Santiago-Tirado - Infection and Immunity, 2023 - Am Soc Microbiol
… (C) Phagosome escape examples: non-lytic exocytosis of C. … of the macrophage; yeast-to-hyphal
transition of C. albicans … manipulation of PIs may play a role in fungal escape from the …

Real-time visualization of phagosomal pH manipulation by Cryptococcus neoformans in an immune signal-dependent way

EJ Santiago-Burgos, PV Stuckey… - Frontiers in Cellular …, 2022 - frontiersin.org
interactions driving disease establishment is Cryptococcus’s … or Mycobacteria, escape from
the phagosome before it acidifies; … albicans’s phagosomes acidify faster in M1 macrophages

Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal–macrophage interaction

…, PR Williamson, A Jedlicka, A Casadevall, C Coelho - …, 2022 - academic.oup.com
phagosomes, may simply reflect the large size of the cryptococcal phagosome, and the fact
that C… We found that Yor1 is not involved in manipulating phagolysosomal pH. To assess any …