Loss of the scavenger receptor MARCO results in uncontrolled vomocytosis of fungi from macrophages

CU Onyishi, Y Jeon, G Fejer… - European Journal of …, 2024 - Wiley Online Library
interaction between MARCO, actin organisation and vomocytosis, we hypothesized that one
role for MARCO may be to sense phagosomal … showing to block phagosome fusion with the …

Dendritic Cells: Multifunctional Roles in Host Defenses to Cryptococcus Infections

KD Goughenour, AS Nair, J Xu, MA Olszewski… - Journal of Fungi, 2023 - mdpi.com
… neoformans is capable of modulating the phagosome’s pH and … evasion strategy of C.
neoformans is the induction of lysosomal damage, which favors its survival inside macrophages. …

Mapping lipid pathways during phagocytosis

O Saharan, SS Kamat - Biochemical Society Transactions, 2023 - portlandpress.com
… of our body, such as macrophages. Lipids play an important … the lipid composition of maturing
phagosomes is important, as … able to evade our immune system during infections [18,19]. …

Vomocytosis of Cryptococcus neoformans cells from murine, bone marrow-derived dendritic cells

N Pacifici, M Cruz-Acuña, A Diener, A Tu, N Senthil… - PloS one, 2023 - journals.plos.org
… of macrophages (MΦ) for extended times, then escape without … capsule, drug manipulation
of the phagosome conditions and … of CN’s complex interactions with different phagocytic cell …

Mitochondrial Morphology, Oxidative Stress Resistance, and Pathogenesis in Cryptococcus neoformans

AL Chang - 2020 - openscholarship.wustl.edu
macrophages after being inhaled into the lungs. In conditions of immunocompromise,
cryptococcal cells can escape … alter this balance by genetic manipulation, starting with perturbation …

Metabolic homeostasis in fungal infections from the perspective of pathogens, immune cells, and whole-body systems

H Weerasinghe, H Stölting, AJ Rose… - … and Molecular Biology …, 2024 - journals.asm.org
… required inside macrophages (with phagosomes thought to … after escape, competing for
glucose with macrophages although it … Understanding how we could manipulate metabolism to …

[HTML][HTML] Programmed cell death: central player in fungal infections

G Camilli, M Blagojevic, JR Naglik, JP Richardson - Trends in cell biology, 2021 - cell.com
… Epithelial damage and manipulation of macrophage apoptosis … may favor fungal escape
from macrophage killing, although … through a FAS/FASL interaction in murine macrophages [ …

… Pandemic Response Box Reveals an Association between Antifungal Effects of MMV1593537 and the Cell Wall of Cryptococcus neoformans, Cryptococcus deuterogattii, and …

HC de Oliveira, RF Castelli, FCG Reis… - Microbiology …, 2022 - Am Soc Microbiol
… effects or toxicity to mammalian macrophages, we selected compound MMV1593537 as a …
the Cryptococcus genus (24). The assembly of the capsule depends on the proper interaction

Fungal melanin-induced metabolic reprogramming in macrophages is crucial for inflammation

Q Chen, F Liu, Y Wu, Y He, Q Kong, H Sang - Journal of Medical Mycology, 2023 - Elsevier
… (HIF1α) and phagosomal recruitment of mammalian target of … transduces activating signals
following interaction with any of … antimicrobial compounds is vital to fungal immune escape. …

The multiplicity of infection does not affect interactions between Cryptococcus neoformans and macrophages

K Pline, S Johnston - bioRxiv, 2020 - biorxiv.org
… (ie the number of cryptococci within the macrophage phagosome). However, as the …
cooperated at higher fungal doses to evade immune capture, or to escape from the phagocyte. This …