Single-cell RNA sequencing reveals the tissue-specific immune signatures of lung cancer with COPD overlapped

H Meng, J Chang, B Wang, B Geng, R He, B Hao… - 2022 - researchsquare.com
… matched smokers with normal lung function, smokers with … moderate to severe chronic
obstructive pulmonary disease. All … T cells were usually divided into CD8+ T cell, CD4+ T cell, and …

… and T-cell responses against SARS-CoV-2 variants by heterologous CoronaVac/ChAdOx-1 vaccination in elderly subjects with chronic obstructive pulmonary disease

W Chaiwong, N Takheaw, S Pata, W Laopajon… - Vaccine, 2023 - Elsevier
… , body mass index (BMI), smoking history, and comorbidities, as … the activation of CD4 T-cell
subsets and CD8 T-cell responses. … , and prevention of chronic obstructive lung disease. The …

[HTML][HTML] Unraveling the pathogenesis of asthma and chronic obstructive pulmonary disease overlap: focusing on epigenetic mechanisms

YC Chen, YP Chang, KT Huang, PY Hsu, CC Hsiao… - Cells, 2022 - mdpi.com
obstruction, typically caused by smoking or biomass, and is associated with neutrophilic
inflammation involving CD4/CD8lung injury-repair processes of chronic lung diseases [52,53]. …

Deciphering the Genetic Architecture of Chronic Obstructive Pulmonary Disease (COPD): Insights from the UK Biobank and Mendelian Randomization Analysis

J Cui, Q Quan, Y Zhang, X Wei, G Li, L Zhu, P Ran - 2024 - researchsquare.com
… characterized by the obstruction of lung airways and di culty … to environmental triggers, such
as smoking, and play a signi … correlated with Plasma cells and T cells CD8. Conversely, the …

[图书][B] Characterising the regional immunity of lung disease

RJ Edge - 2020 - search.proquest.com
… T cells can be divided into two key elements, CD4+ or CD8+ … chronic lung disease: chronic
obstructive pulmonary disease (… smoking [38]. Traditionally, COPD has been considered as a …

An Integrated Systems Approach to Infer Protein Networks Associated with Chronic Obstructive Pulmonary Disease

K DiLillo - 2023 - deepblue.lib.umich.edu
… a study that showcases how lung CD8+ T cells from COPD patients … response to cigarette
smoke, airway epithelial cells and alveolar … of T cells into the lung. Following infiltration into the …

[HTML][HTML] Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease

P Liu, Y Wang, N Zhang, X Zhao, R Li, Y Wang… - Respiratory …, 2022 - Springer
lung tissue of COPD patients compared with normal smokers … /tracheal epithelial cells
compared with undifferentiated cells [… lung function and is associated with the genetics of smoking

[HTML][HTML] Sexual dimorphism in chronic respiratory diseases

KD Reddy, BGG Oliver - Cell & Bioscience, 2023 - Springer
… as chronic obstructive pulmonary disease (COPD) and lung … + to CD8 + cell ratio can be a
marker of chronic lung disease. … increased lung cancer cases in never-smoking individuals, …

Role of mast cells in an in-vivo model of COPD-associated inflammation

E Danielsson - 2020 - diva-portal.org
… in lung-infiltrating cells, (eg neutrophils, CD4+ and CD8+ T-… with exposure to lung irritants,
such as cigarette smoke (CS). A … model of chronic obstructive pulmonary disease identifies a …

What Every Clinician Should Know About Inflammation in COPD

ME Wechsler, JM Wells - ERJ Open Research, 2024 - Eur Respiratory Soc
Chronic obstructive pulmonary disease is defined by the Global Initiative for Chronic
Obstructive Lung Disease (GOLD) as “a … CD8+ve cells in the lungs of smokers with chronic