… NTG-induced trigeminal hyperalgesia, we first tested two doses of the CGRP receptor
antagonist in the acute animal model of migraine on the basis of a single NTG (10 mg/kg, ip) …

… in CGRP- and PACAP-mediated migraine pain, we used mouse models of provoked migraine-…
Genetically modified mice lacking either functional CGRP receptors (Ramp1 knockout) or …

… The present studies developed and characterized a preclinical model of migraine that … role
for the CGRP receptor in migraine-like pain. In these circumstances, antagonism of the CGRP …

… Animal models of CM have contributed to our … CGRP receptor antagonists and CGRP
monoclonal antibodies [6, 7]. In basic research, the establishment and selection of animal models …

… CGRP as a migraine relevant target (2,3) without distinct knowledge about its site and mechanism
of action in migraine … documented CGRP dependency of GTN animal models (27,35,36…

… While the discussion on the involvement of inflammation in migraine pathophysiology is
continued, many inflammation and pain sensitization animal models have been developed. …

… ) in animal models, 9,44 we examined whether similar changes occur in a mouse model of
mild … -2 (ld-IL2) treatment that reverses chronic migraine-related and PTH-related behaviors. …

… A variety of animal models that mimic features of migraine have been developed and will
be discussed in this review. Cluster headache is another primary headache involving …

… Accordingly, in the present study, we reported that the decrease in CGRP plasma levels
and gene expression was associated with a significant reduction of TNF-alpha and IL-6 gene …

… GTN migraine model. One could argue that if the causative CGRP release of a true migraine
… However, CGRP was not increased in blood from the internal jugular vein draining the brain …