[HTML][HTML] MiRNA-Mediated Subpathway Identification and Network Module Analysis to Reveal Prognostic Markers in Human Pancreatic Cancer

Y Liu, Y Cui, X Bai, C Feng, M Li, X Han, B Ai… - Frontiers in …, 2020 - frontiersin.org
Pathway analysis is the first choice to gain insight into biological processes and understand
… developed time-vaRying enriCHment integrOmics Subpathway aNalysis tOol (CHRONOS) …

mirTime: identifying condition-specific targets of microRNA in time-series transcript data using Gaussian process model and spherical vector clustering

H Kang, H Ahn, K Jo, M Oh, S Kim - Bioinformatics, 2021 - academic.oup.com
… From the gene set enrichment analysis, we found that 83 of the 132 genes belong to the ‘protein
binding’ (GO: 0005515, P-value: 1.3E-5) and 41 genes belong to ‘extracellular exosome…

Pathway Analysis for unraveling Complex Diseases: Current State and Future Perpectives

AG Vrahatis, P Vlamos, A Avramouli… - 2020 5th South-East …, 2020 - ieeexplore.ieee.org
… emerging subpathway analysis field while we identify major challenges that the next generation
of methods … by the tools named Graphite [39], Subpathway-GM [38], and CHRONOS [40]. …

Identification of differentially expressed subpathways via a bilevel consensus scoring of network topology and gene expression

P Balomenos, A Dragomir, AK Tsakalidis… - 2020 42nd Annual …, 2020 - ieeexplore.ieee.org
subpathway analysis method to identify differentially expressed … A recent trend in pathway
analysis is to consider localized … , “CHRONOS: a time-varying method for microRNA-mediated

A systems biology approach for the identification of active molecular pathways during the progression of Alzheimer's disease

AG Vrahatis, IS Kotsireas, P Vlamos - GeNeDis 2018: Computational …, 2020 - Springer
… Our proposed approach is based on the emerging fourth generation of pathway analysis,
the subpathway analysis, by using … CHRONOS makes assumptions in order to convert the …

Identifying Network Biomarkers for Alzheimer's Disease Using Single-Cell RNA Sequencing Data

I Aslanis, MG Krokidis, GN Dimitrakopoulos… - Worldwide Congress on …, 2022 - Springer
… -perturbed subpathways within a pathway network… pathway analysis detection [34,35,36].
Of note, in recent literature, the focus has shifted from pathway analysis to subpathway analysis

Detecting Active Molecular Subpathways Related to Alzheimer's Disease: A Systems Biology Approach

AG Vrahatis, P Vlamos - Handbook of Computational Neurodegeneration, 2023 - Springer
… Methodological Steps of Pathway Analysis Biological pathway analysis is a set of Systems
Biology techniques that are used to extract knowledge from high-throughput sequencing data …

A Systems Biology Approach for Detecting Active Molecular Subpathways Related to Alzheimer's Disease

AG Vrahatis, P Vlamos - Handbook of Computational Neurodegeneration, 2021 - Springer
… Methodological Steps of Pathway Analysis Biological pathway analysis is a set of Systems
Biology techniques that are used to extract knowledge from high-throughput sequencing data …

[HTML][HTML] Identification of informative genes and sub-pathways using Improved Differential Expression Analysis for Pathways (iDEAP) for cancer classification

NA Nasarudin, MS Mohamad, Z Zakaria… - …, 2023 - f1000research.com
sub-pathway-based analysis method, that identifies a local region perturbed by complex
diseases based on larger pathway … expression analysis for the pathway (iDEAP) method which …

Network biomarkers for Alzheimer's disease via a graph-based approach

AG Vrahatis, P Vlamos, M Gonidi… - 2020 5th South-East …, 2020 - ieeexplore.ieee.org
… biological hypothesis of CHRONOS package [29]. Metabolic pathway maps include enzyme
enrichment analysis to highlight the most relevant terms associated with a given gene list. …