… on COX-2, and the other mechanism acts through a signaling pathway independent of
COX-2. … -initiated cell cycle arrest at the G0/G1 phase via the activation of p21 and subsequent …

… Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) … of p53 and its downstream
target p21 in the combined group, … on how metformin inhibits ERK signaling without causing …

… ) on lung adenocarcinoma in spontaneous lung cancer mouse … apoptosis (p21, caspase-3)
in the lung tumors exposed to … literature suggest that naproxen inhibits COX‐2-derived PGE …

… of the selective COX-2 inhibitor celecoxib that lacks COX-2-… using unpaired Student’s t test
for at least three independent … of cell cycle arrest protein P21 increased in all the four GBM …

… We found that COX-2 inhibits the pro-senescent function of p53 … that COX-2 prevents
OIS under strong mitogenic signals, by … In addition, the p53 transfection induced p21 CIP1/WAF1 …

… and p21/WAF1 (p21) are crucial for cell cycle progression; p21 … verified to inhibit cell growth
and induce partial apoptosis (28), … indicated in the study and/or disrupting of COX-2 activity …

… of all immunostains by two independent observers. In the … the P53 signals as the molecular
mechanism involved in cell … An analysis of the translational level of P53 and CDN1A (p21…

… Selective COX-2 inhibitors (celecoxib and NS-398) were … The data are represented as mean
± SEM from three separate … PKCδ/p53/p21 Cip1 and PKCα/MAPK signaling pathways [30]. …

… CDK blockers (p21, p27) and COX-2, which lead to NSCLC … In this study design, we did not
consider a separate group for … suppression of lung carcinogenesis of COX-2 inhibition and …

… COX-2-PGE 2 -EPs signaling in endometrial cancer, ovarian … As an independent prognosticator
for cervical carcinoma, the … cancer, urothelial cancer and non-small cell lung cancer [18]. …