… to attenuate renal injury in a murine lupus model [26]. As the effect of CSF-1R inhibition
on AKI progression is not fully understood, we explored the role of a CSF-1R inhibitor in …

… Neuropsychiatric systemic lupus erythematosus (NPSLE) has a broad spectrum of subtypes
… for managing this disease. The attenuation of neuropsychiatric disease in mouse models …

… with disease activity scores in SLE patients, and blocking CXCL13 in lupus mice attenuated
renal disease (15… and disease progression, but its role has not been studied in the context of …

… in an in vitro model of mouse bone-marrow-derived … inhibitor-ACEi) suppressed Type I
IFN responsive gene (IRG) expression. In this report, we used the MRL/lpr lupus-prone mouse …

… Modification or depletion of macrophages and microglia with various targets such as CSF-1R
or lipocalin-2 was shown to attenuate neuropsychiatric manifestations in MRL/lpr mice.148.…

… would attenuate the manifestations of NPSLE and disrupt TLS formation. Using the MRL/lpr
mouse model, we treated mice with … CSF-1R inhibition attenuates renal and neuropsychiatric …

… , deficits in sociability and cognitive impairments in NZB/W F1 lupus-prone mice [Citation93],
but anti-IFNAR treatment failed to reverse NP disease in the MRL/lpr model [Citation94]. …

… Here we demonstrate that CReCOM mice also display NP-SLE-like disease. CReCOM
mice … Similar to these findings in MRL lpr/lpr mice, the lack of systemic disease attenuation …

… These markers might play pathogenic roles in lupus nephritis. For example, the CD115
inhibitor GW2580 attenuates nephritis and neuropsychiatric diseases in the lupus-prone mouse …

… CSF1R inhibitors afford the most extensive versatility in manipulating microglia, making
them ideal candidates for future studies investigating microglial function in health and disease. …