CXCR4-targeted theranostics in oncology

AK Buck, SE Serfling, T Lindner, H Hänscheid… - European Journal of …, 2022 - Springer
… blood cancer. In the present review, we will provide an overview of CXCR4-directed molecular
… patients and, thus, may even provide a more reliable read-out of ongoing inflammatory

In vivo targeting of CXCR4—new horizons

M Schottelius, K Herrmann, C Lapa - Cancers, 2021 - mdpi.com
theranostics in cancer, this review primarily focuses on imaging of a broad spectrum of
inflammatory … on macrophages and T cells, CXCR4-directed molecular imaging provides the …

Synthesis, Screening, and Evaluation of Theranostic Molecular CPCR4-Based Probe Targeting CXCR4

T Yang, D Shi, Q Lin, H Shen, H Tan, Y Liu… - Molecular …, 2024 - ACS Publications
… The objective of this study was to synthesize theranostic molecular tracers with superior
CXCR4 targeting functions. The Daudi cell line, which highly expressed CXCR4, and the MM.1S …

Novel Theranostic Approaches Targeting CCR4-Receptor, Current Status and Translational Prospectives: A Systematic Review

J Gorica, MS De Feo, F Corica, MMA Sidrak, M Conte… - Pharmaceuticals, 2023 - mdpi.com
… expression of CCR4 in human gastric cancer. Feasibly suppressing CCR4 expression …
Radiation produces pro-inflammatory factors to recruit TILs and change the inflammatory

[HTML][HTML] A new class of PentixaFor-and PentixaTher-based theranostic agents with enhanced CXCR4-targeting efficiency

T Osl, A Schmidt, M Schwaiger, M Schottelius… - Theranostics, 2020 - ncbi.nlm.nih.gov
… in cancer and inflammation as well as CXCR4-targeted radioligand therapy (RLT) have
recently found their way into clinical research by the development of the theranostic agents [ 68 …

[PDF][PDF] CXCR4 Theranostics: A Potential Game Changer in Solid Tumors and Hematological Malignancies

S Baljinder, W Ankit, AS Shekhawat… - … Oncology: Festschrift …, 2024 - library.oapen.org
… These include its inability to differentiate inflammatory/infectious pathologies from tumor …
serve as a prerequisite for potential CXCR4-directed radio-chemotherapies. In a preliminary …

Chemokine Receptor CXCR4 Radioligand Targeted Therapy Using 177Lutetium-pentixather for Pulmonary Neuroendocrine Cancers

MA Fath, D Liu, JT Ewald… - Radiation …, 2024 - meridian.allenpress.com
theranostics (5). Currently there are phase 1 clinical trials testing CXCR4 targeted radionuclides
for cancer … blinded pathologist for tubuloninterstitial inflammation, interstitial fibrosis, and …

CXCR4-targeted radiopharmaceuticals for the imaging and therapy of malignant tumors

J Yu, X Zhou, L Shen - Molecules, 2023 - mdpi.com
inflammatory diseases, and metastatic cancer, including breast cancer, gastric cancer, and
non-small cell lung cancer… possibility of this radiotracer pair as a theranostic pair [64]. Further, …

Advances in PET imaging of the CXCR4 receptor:[68Ga] Ga-PentixaFor

L Lindenberg, M Ahlman, F Lin, E Mena… - Seminars in Nuclear …, 2024 - Elsevier
… in oncology, cardiology and inflammatory disease. Preclinical work in various cancer cell …
clinical exploration with potential for theranostic applications in hematologic malignancies. …

Theranostics in hematooncology

AK Buck, SE Serfling, S Kraus, S Samnick… - Journal of Nuclear …, 2023 - Soc Nuclear Med
… of CXCR4-directedOncology in 2022, an expert panel of hematooncologists and nuclear
medicine physicians discussed potential clinical applications of CXCR4-targeted theranostics. …