Epigenetic connection of the calcitonin gene-related peptide and its potential in migraine

M Fila, A Sobczuk, E Pawlowska, J Blasiak - International journal of …, 2022 - mdpi.com
… antibodies against the calcitonin gene-related peptide (CGRP) … In conclusion, central and
peripheral actions of CGRP may … in the inflammatory reaction that may play a role in migraine

Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting

AS Wattiez, LP Sowers, AF Russo - Expert opinion on therapeutic …, 2020 - Taylor & Francis
… of the neuropeptide calcitonin gene-related peptide (CGRP), … supports a peripheral role
of CGRP in migraine since the … of these other peptides and pro-inflammatory cytokines and …

Can calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX-3) be useful in diagnosing acute migraine attack?

S Vural, L Albayrak - Journal of Receptors and Signal Transduction, 2022 - Taylor & Francis
… of Calcitonin Gene-Related Peptide (CGRP) and Pentraxin-3 (PTX-3) in acute migraine.
To … change in vascular inflammation during pathological processes of migraine because it …

Calcitonin gene-related peptide antagonists for the prevention of migraine: highlights from pivotal studies and the clinical relevance of this new drug class

K Arca, J Reynolds, KA Sands… - Annals of …, 2020 - journals.sagepub.com
… drug class of calcitonin gene-related peptide antagonists (… of neurogenic inflammation.
CGRP increases during … safe in those with comorbid peripheral and cerebrovascular conditions. …

CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond

AF Russo, DL Hay - Physiological reviews, 2023 - journals.physiology.org
… actions in both the peripheral and central nervous systems … Calcitonin gene-related peptide
(CGRP) is a neuropeptide … inflammatory signals, such as sepsis and possibly migraine. …

Neurogenic inflammation: The participant in migraine and recent advancements in translational research

E Spekker, M Tanaka, Á Szabó, L Vécsei - Biomedicines, 2021 - mdpi.com
… In a clinical study, during the interictal period of chronic migraine, higher VIP levels have been
reported in peripheral venous blood than in control … CGRP calcitonin gene-related peptide

Neuroanatomical evidence and a mouse calcitonin generelated peptide model in line with human functional magnetic resonance imaging data support the …

A Al-Omari, B Gaszner, D Zelena, K Gecse, G Berta… - Pain, 2022 - journals.lww.com
migraine. Using RNAscope in situ hybridization and immunostaining, we examined the
expression of calcitonin generelated peptide … system (CNS) and periphery. Potential targets may …

Migraine pathways and the identification of novel therapeutic targets

I Rainero, F Roveta, A Vacca, C Noviello… - Expert Opinion on …, 2020 - Taylor & Francis
… the headache phase of the migraine attack both peripheral … antibodies against calcitonin
gene-related peptide (CGRP) or … , showing that migraine is located at the crossroads of several …

Antagonism of CGRP receptor: central and peripheral mechanisms and mediators in an animal model of chronic migraine

R Greco, C Demartini, M Francavilla, AM Zanaboni… - Cells, 2022 - mdpi.com
calcitonin gene-related peptide (CGRP) in the development of sensitization and enhanced
pain sensibility that characterize migraineinflammatory mediators released during a migraine

Neurogenic Inflammation: One of the Participants of Migraine and the Contribution of Translational Research

E Spekker, M Tanaka, Á Szabó, L Vécsei - 2021 - preprints.org
… , AF Calcitonin gene-related peptide in migraine: intersection of … Calcitonin gene-related
peptide is present in mammalian cerebrovascular nerve fibres and dilates pial and peripheral