… can also <e intentionally engineered to accept SAM analogs as su<… one of two heRГ2Гynyl
side chains termed either AdoГ6Гamine … enzymes to study eukaryotic DNA methylation: I. The …

… , your continuous support and guidance that I received … was started around 100 years
ago, when 5-methylcytosine (… range of GTP analogs with various functional groups at the 2’…

… OH Cyt nucleobase instead of Cyt or 5-methylcytosine ( m Cyt) (2… for the 5-hydroxycytidine
analogues, especially focusing on … The coupling time was prolonged to 12.5 min for amidites 6 …

… and in the removal of an epigenetic mark (5-methylcytosine). … ALKBH3 is lined with side
chain radicals of positively charged … hm 5 C, DNA methylation can no longer be preserved even …

… an epigenetic marker to counteract DNA methylation in regulating … total synthesis of P1 and
its analogs presents a great challenge to … the requisite 4-carbon side chain at the C5 position. …

… of the O6-CMG analogs on polymerase fidelity. While Pol κ … to form DNA adducts results
from nucleophilic attack of alkyl-… and guidance in creating the Building Chemical Bonds series. …

… analogues have shown success through introducing alkyl … a change to the amino acid
side chain. Synthesis of the cofactors … found within somatic cells this is where 5-methylcytosine …

… This rearrangement has an influence on other parts of the protein, more specifically on
the side chain of L184 which is forced to rotate and blocks the O2 diffusion tunnel. …

… While the impact of DNA methylation, in the form of … two tracts and long tracts of Cyt-rich
repeats can fold under in vitro … that incorporation of four consecutive 5-methylcytosine (m5Cyt) …

… Epigenetic marks of DNA such as 5-methylcytosine control … Changes in DNA methylation
patterns can lead to silencing of … stable isotope-labeled analogues of each nucleoside that are …