… have identified glucose metabolism abnormalities in aging, … in aging, resulting in aggregates
that exert negative effects on … preserved metabolism of ketones, which could compensate …

… has several overlapping metabolic effects with ketones, we … brain glucose transport (eg
cerebral perfusion, blood– brain … Thus, ketones effectively compensate for at least part of the …

… in cerebral glucose consumption while oxygen use was unchanged, suggesting that … , E.;
Castellano, CA Can ketones compensate for deteriorating brain glucose uptake during aging? …

… , considering the multifaceted effects of the ketone bodies in … a reduction in brain glucose
uptake because ketone bodies … , neuronal survival, brain aging, and memory function. Insulin …

… that could compensate for the deficient glycolytic metabolism … , the consumption of glucose
can reverse deteriorating … MMKD facilitated cerebral uptake of ketones while glucose uptake …

… We propose that this glucose-sparing effect of ketone bodies may underlie the effectiveness
… glucose metabolism may lead to energy deficiency that ketones can partially compensate by …

… In the adult brain, ketone body metabolism is increased in … This important feature suggests
that brain glucose uptake is not insulin-… Implications for cognitive health during aging and the …

… humans has demonstrated reduced glucose uptake in insulin-… d-βHb ketone ester has brain
network stabilizing effects even … al., Can ketones compensate for deteriorating brain glucose …

… Ketosis-evoked neuroprotective effects may lead to … the activity of the Nrf2 in the brain likely
through βHB/HCAR2/AMPK/… For example, increased level of βHB can compensate glucose …

… induced by substrates such as glucose, lactate, and ketone … tissues, suggesting that glucose
uptake may compensate for Aβ … brain glucose metabolism declines with normal aging and …