The Endocannabinoid System in the Mediterranean Mussel Mytilus galloprovincialis: Possible Mediators of the Immune Activity?

F Mosca, O Zarivi, N Battista, M Maccarrone… - International Journal of …, 2021 - mdpi.com
… immunosuppressive response in immunocytes from Mytilus … receptor identified in an
invertebrate species, we performed … exert their biological actions via coupling to nitric oxide (NO) …

The endocannabinoid system and invertebrate neurodevelopment and regeneration

TL Clarke, RL Johnson, JJ Simone… - International journal of …, 2021 - mdpi.com
… -coupled receptors (GPCRs), the cannabinoid receptor type-… signaling and nitric oxide in
microglial activation and chemotaxis … fashion to inhibit an immunocyte response to evade host …

Microglial phenotypes and their relationship to the cannabinoid system: therapeutic implications for Parkinson's disease

R Kelly, V Joers, MG Tansey, DP McKernan, E Dowd - Molecules, 2020 - mdpi.com
… system, expressing the cannabinoid receptors in addition to … this evidence combined does
suggest that the microglia play a … , such as the enzymes inducible nitric oxide synthase (iNOS) …

Characterization of Cannabinoid Receptors in the Peripheral Nervous System and in the Gastrointestinal Tract of Mammals of Veterinary Interest

G Galiazzo - 2020 - amsdottorato.unibo.it
… These proteins are conserved in invertebrates and vertebrates. TRP are widely … immunocytes
bearing cannabinoid receptors. The anti-IBA1 antibody should recognize CNS microglia (…

The Endocannabinoid System and Invertebrate Neurodevelopment and Regeneration

B Carlone - 2021 - dr.library.brocku.ca
… -coupled receptors (GPCRs), the cannabinoid receptor type-… signaling and nitric oxide in
microglial activation and … fashion to inhibit an immunocyte response to evade host immune …

CannabinEYEds: the endocannabinoid system as a regulator of the ocular surface nociception, inflammatory response, neovascularization and wound healing

F Aiello, G Gallo Afflitto, JPO Li, A Martucci… - Journal of Clinical …, 2020 - mdpi.com
… system, highly conserved among vertebrates. It has been widely … nitric oxide release through
binding to their specific receptor [… These are G-proteins coupled receptors (GPCRs) able to …

2-Arachidonoylglycerol as an Endogenous Cue Negatively Regulates Attachment of the Mussel Perna viridis

Q Dai, ZX Wang, YQ Sheng, ZW Wu, Y Qiu… - Frontiers in Marine …, 2021 - frontiersin.org
… attachment in benthic invertebrates are poorly understood. … may stimulate nitric oxide (NO)
release from immunocytes of M. … 1 and 2 (CB1 and CB2, two G-protein-coupled receptors) was …

Endocannabinoid system as a promising therapeutic target in inflammatory bowel disease–a systematic review

S Hryhorowicz, M Kaczmarek-Ryś, A Zielińska… - Frontiers in …, 2021 - frontiersin.org
… oxygen species (ROS), and nitric oxide release (7). This review … found in invertebrate
immunocytes and microglia and are … orphan G-protein-coupled receptors. The close phylogenetic …

Cannabinoid 1 and mu-opioid receptor agonists synergistically inhibit abdominal pain and lack side effects in mice

Y Yu, QK Tsang, J Jaramillo-Polanco… - Journal of …, 2022 - Soc Neuroscience
… was inhibited by neuronal nitric oxide synthase and guanylate … stimulates NO release from
immunocytes, microglia, and … hydromorphone combined with several oral doses of Δ9-THC; …

[PDF][PDF] Efficacy of utilizing cannabidiol in reduction of inflammation and autoimmunity manifestation

S Ghasemi, P Davoodi, FMA Boojar… - Open Access Research …, 2022 - oarjbp.com
… effects through cannabinoid receptors. Inflammation is … from lower invertebrates to higher
mammals [7]. Endogenous … / or heterotrimeric protein-coupled receptors and are expressed in …