Mechanism and potential treatment of the “no reflow” phenomenon after acute myocardial infarction: role of pericytes and GPR39
C Methner, Z Cao, A Mishra… - American Journal of …, 2021 - journals.physiology.org
… We conclude that GPR39-mediated pericyte contraction during reduced coronary perfusion
pressure causes capillary constriction resulting in no reflow during AMI and that smaller …
pressure causes capillary constriction resulting in no reflow during AMI and that smaller …
Mechanisms of the “no-reflow” phenomenon after acute myocardial infarction: Potential role of pericytes
… in coronary no reflow in a rat model of myocardial ischemia and reperfusion. They noted
that 40% of capillaries had no reflow at pericyte … during ischemia from greater pericyte-mediated …
that 40% of capillaries had no reflow at pericyte … during ischemia from greater pericyte-mediated …
[HTML][HTML] Ischemia preconditioning alleviates ischemia/reperfusion injury-induced coronary no-reflow and contraction of microvascular pericytes in rats
Q Li, Z Guo, C Wu, Y Tu, Y Wu, E Xie, C Yu, W Sun… - Microvascular …, 2022 - Elsevier
… that pericyte mediated coronary no-reflow, and how IPC alleviate pericyte constriction to
reduce capillary … during acute myocardial ischemia/reperfusion injury, and IPC could inhibit the …
reduce capillary … during acute myocardial ischemia/reperfusion injury, and IPC could inhibit the …
Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia
F Freitas, D Attwell - Elife, 2022 - elifesciences.org
… constriction of capillary pericytes as the underlying cause of post- ischemia renal no- reflow
conditions, which contribute to kidney injury in a variety of settings, including cardiac surgery, …
conditions, which contribute to kidney injury in a variety of settings, including cardiac surgery, …
The fate and role of the pericytes in myocardial diseases
NG Frangogiannis - European Journal of Clinical Investigation, 2024 - Wiley Online Library
… This review manuscript discusses the role of pericytes in cardiac homeostasis and disease.
… Capillary pericytes mediate coronary noreflow after myocardial ischaemia. eLife. 2017;6:…
… Capillary pericytes mediate coronary noreflow after myocardial ischaemia. eLife. 2017;6:…
Persistent coronary vasomotor tone during myocardial ischemia occurs at the capillary level and may involve pericytes
… We demonstrated that pericyte contraction was mediated by … inhibitor exhibited better
capillary density, less no reflow, and … that pericyte contraction could lead to capillary constriction, …
capillary density, less no reflow, and … that pericyte contraction could lead to capillary constriction, …
Coronary No-Reflow after Primary Percutaneous Coronary Intervention—Current Knowledge on Pathophysiology, Diagnosis, Clinical Impact and Therapy
G Ndrepepa, A Kastrati - Journal of Clinical Medicine, 2023 - mdpi.com
… elevation myocardial infarction (STEMI) following reperfusion … of cerebral ischemia, pericytes
caused capillary constriction … ischemic preconditioning may be at least partially mediated …
caused capillary constriction … ischemic preconditioning may be at least partially mediated …
No-reflow post-recanalization in acute ischemic stroke: mechanisms, measurements, and molecular markers
CP Sperring, WM Savage, MG Argenziano, VP Leifer… - Stroke, 2023 - Am Heart Assoc
… large vessels and ECs and pericytes in capillaries. In the setting … setting of myocardial
infarction, the no-reflow phenomenon … are considered to be mediators of an inflammatory cascade, …
infarction, the no-reflow phenomenon … are considered to be mediators of an inflammatory cascade, …
The role of cardiac pericytes in health and disease: therapeutic targets for myocardial infarction
… Capillary pericytes are one of the most abundant cell … previous ischaemic injury has impaired
pericyte-mediated healing … The most common cause of no-reflow is the rise in intracellular …
pericyte-mediated healing … The most common cause of no-reflow is the rise in intracellular …
Coronary No-reflow After Primary Percutaneous Coronary Intervention–Current knowledge on Diagnosis, Pathophysiology, Clinical Impact and Therapy
G Ndrepepa, A Kastrati - 2023 - preprints.org
… elevation myocardial infarction (STEMI) following reperfusion … of cerebral ischemia, pericytes
caused capillary constriction … ischemic preconditioning may be at least partially mediated …
caused capillary constriction … ischemic preconditioning may be at least partially mediated …