[HTML][HTML] Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

S Akula, L Hellman, FX Avilés, S Wernersson - … & Comparative Immunology, 2022 - Elsevier
… Interestingly, in the lack of CPA3 in fishes, zebrafish MCs … findings clarify and add to our
understanding of the evolution of … and a loss of both A4 and A5 and a duplication of the CPA1 …

Carboxypeptidase A3—a key component of the protease phenotype of mast cells

D Atiakshin, A Kostin, I Trotsenko, V Samoilova… - Cells, 2022 - mdpi.com
… presence of carboxypeptidases B1 or A2 in mast cells (Figure 6… localization of pancreatic
carboxypeptidases and tryptase only … In addition, cells containing pancreatic carboxypeptidases

[HTML][HTML] Zebrafish as a model for inflammation and drug discovery

R Zanandrea, CD Bonan, MM Campos - Drug Discovery Today, 2020 - Elsevier
zebrafish. Therefore, in-depth studies of the specific functions of microbial recognition receptors
in zebrafish are still required to gain further insightsmast cell degranulation; in zebrafish; …

Quantitative in-depth analysis of the mouse mast cell transcriptome reveals organ-specific mast cell heterogeneity

S Akula, A Paivandy, Z Fu, M Thorpe, G Pejler… - Cells, 2020 - mdpi.com
mast cells also express an MC-specific carboxypeptidase- … identified proteins in MC biology
may also give new insightsZebrafish MC-like cells have also been shown to stain positive …

Insights into the Characteristics and Functions of Mast Cells in the Gut

Y Guo, B Wang, H Gao, C He, S Xin, R Hua… - … Insights, 2023 - mdpi.com
… Based on MC-specific proteases of chymase, tryptase, or carboxypeptidase A(MC-CPA)
type, mast cells can be classified into MC T and MC TC in human beings [21,22] and MMC as …

Zebrafish: an underutilized tool for discovery in host–microbe interactions

A Stream, CA Madigan - Trends in immunology, 2022 - cell.com
… technology, which is constantly evolving and providing newzebrafish model – which
remains underutilized in immunology – provides fertile ground for a new understanding

Single‐cell transcriptome profiling reveals diverse immune cell populations and their responses to viral infection in the spleen of zebrafish

CB Hu, J Wang, Y Hong, H Li, DD Fan… - The FASEB …, 2023 - Wiley Online Library
… express cpa5 (carboxypeptidases), a specific marker of zebrafish mast cellCarboxypeptidase
A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell

Identification of a specific granular marker of zebrafish eosinophils enables development of new tools for their study

M Herbert, C Goosmann, V Brinkmann, C Dimmler… - bioRxiv, 2024 - biorxiv.org
… Based on our findings, we are able to identify our 58 … Carboxypeptidase A5 identifies a
novel mast cell lineage in 446 the zebrafish providing new insight into mast cell fate determination…

Discovery of granulocyte-lineage cells in the skin of the amphibian Xenopus laevis

K Hauser, M Popovic, A Yaparla, DV Koubourli… - Facets, 2020 - facetsjournal.com
… This manuscript provides new insights into the composition … laevis esterase-positive skin
cells were mast cells, we stained … mast cell carboxypeptidase, used as a marker of zebrafish

… relevant are bone marrow-derived mast cells (BMMCs) as models for tissue mast cells? A comparative transcriptome analysis of BMMCs and peritoneal mast cells

S Akula, A Paivandy, Z Fu, M Thorpe, G Pejler… - Cells, 2020 - mdpi.com
… a MC-specific carboxypeptidase, named carboxypeptidase A3 (… BMMCs have also been
instrumental for our understanding of … role in MC development in zebrafish, whereas Gata1 does …