Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice
… female mice in the OR486 + sham group exhibited increased … (E) No sexually dimorphic
effects were observed following … stressful events which potentiate catecholamine release from …
effects were observed following … stressful events which potentiate catecholamine release from …
Catechol-O-methyltransferase and pregnancy outcome: an appraisal in rat
… is an enzyme involved in the catabolism of catecholamines and other molecules possessing
a … Mouse exhibits shallow trophoblast invasion and is not an optimal model for investigating …
a … Mouse exhibits shallow trophoblast invasion and is not an optimal model for investigating …
[HTML][HTML] Female-specific effects of the catechol-O-methyl transferase Val158Met gene polymorphism on working memory-related brain function
… the left inferior temporal gyrus exhibited higher activation in Met … dimorphic changes caused
by COMT deficiency [20, 21]. … This sex-genotype interaction may reflect sexually dimorphic …
by COMT deficiency [20, 21]. … This sex-genotype interaction may reflect sexually dimorphic …
Catechol-O-Methyltransferase Effects on Smoking: A Review and Proof of Concept of Sex-Sensitive Effects
EE DeVito, M Sofuoglu - Current behavioral neuroscience reports, 2022 - Springer
Purpose of Review This article reviews recent research on how catechol-O-methyltransferase
(COMT) may impact cigarette smoking behavior, and how effects may be sex-sensitive. …
(COMT) may impact cigarette smoking behavior, and how effects may be sex-sensitive. …
Catechol-O-methyltransferase activity does not influence emotional processing in men
MAG Martens, N Dalton, J Scaife… - Journal of …, 2022 - journals.sagepub.com
… (1998) Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes
in catecholamine levels and behavior. Proceedings of the National Academy of Sciences 95(17)…
in catecholamine levels and behavior. Proceedings of the National Academy of Sciences 95(17)…
Catechol-O-methyltransferase loss drives cell-specific nociceptive signaling via the enteric catechol-O-methyltransferase/microRNA-155/tumor necrosis factor α axis
QQ Zhou, L Yang, ML Verne, BB Zhang, J Fields… - Gastroenterology, 2023 - Elsevier
… The COMT/catecholamine pathway has been studied for … However, we did not observe
a significant change in transit … Our results here show that anti-TNF therapy can silence miR-…
a significant change in transit … Our results here show that anti-TNF therapy can silence miR-…
Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease
AM Heitzer, SR Rashkin, A Trpchevska… - Current Research in …, 2024 - Elsevier
… age and sex differences across samples. There are notable structural and functional changes
in … These changes include declines in frontal dopamine signaling that differs across COMT …
in … These changes include declines in frontal dopamine signaling that differs across COMT …
The Influence of Genetic Polymorphic Variability of the Catechol-O-methyltransferase Gene in a Group of Patients with a Diagnosis of Behavioural Addiction, including …
R Recław, K Chmielowiec, A Suchanecka, A Boroń… - Genes, 2024 - mdpi.com
… , which is a postsynaptic enzyme that degrades catecholamines (epinephrine, dopamine
and … The psychiatric phenotypes affected by the COMT genotype exhibit sex-specificity [73], …
and … The psychiatric phenotypes affected by the COMT genotype exhibit sex-specificity [73], …
The association of catechol-O-methyltransferase genetic polymorphism rs4680 in physical activity among adult women
L Gotlieb, S Ben-Zaken - bioRxiv, 2022 - biorxiv.org
… The enzyme COMT degrades catecholamines, including dopamine. Two main COMT …
Further research is needed in order to explore the relations between sex hormonal changes …
Further research is needed in order to explore the relations between sex hormonal changes …
Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in …
J Chi, Y Ma, M Shi, C Lu, Q Jiang, Y Li, X Zhang, X Shi… - Brain Research, 2024 - Elsevier
… C allele at rs4818 SNP exhibited significantly better immediate memory and speech functions
compared to G allele carriers. However, our findings did not show any effect of the rs4680 …
compared to G allele carriers. However, our findings did not show any effect of the rs4680 …