Low catechol-O-methyltransferase and stress potentiate functional pain and depressive behavior, especially in female mice

X Zhang, K Kanter, J Chen, S Kim, Y Wang, C Adeyemi… - Pain, 2020 - journals.lww.com
… female mice in the OR486 + sham group exhibited increased … (E) No sexually dimorphic
effects were observed following … stressful events which potentiate catecholamine release from …

Catechol-O-methyltransferase and pregnancy outcome: an appraisal in rat

K Iqbal, P Dhakal, SH Pierce, MJ Soares - Reproductive Sciences, 2021 - Springer
… is an enzyme involved in the catabolism of catecholamines and other molecules possessing
a … Mouse exhibits shallow trophoblast invasion and is not an optimal model for investigating …

[HTML][HTML] Female-specific effects of the catechol-O-methyl transferase Val158Met gene polymorphism on working memory-related brain function

J Fan, C Yang, Z Liu, H Li, Y Han, K Chen… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… the left inferior temporal gyrus exhibited higher activation in Met … dimorphic changes caused
by COMT deficiency [20, 21]. … This sex-genotype interaction may reflect sexually dimorphic

Catechol-O-Methyltransferase Effects on Smoking: A Review and Proof of Concept of Sex-Sensitive Effects

EE DeVito, M Sofuoglu - Current behavioral neuroscience reports, 2022 - Springer
Purpose of Review This article reviews recent research on how catechol-O-methyltransferase
(COMT) may impact cigarette smoking behavior, and how effects may be sex-sensitive. …

Catechol-O-methyltransferase activity does not influence emotional processing in men

MAG Martens, N Dalton, J Scaife… - Journal of …, 2022 - journals.sagepub.com
… (1998) Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes
in catecholamine levels and behavior. Proceedings of the National Academy of Sciences 95(17)…

Catechol-O-methyltransferase loss drives cell-specific nociceptive signaling via the enteric catechol-O-methyltransferase/microRNA-155/tumor necrosis factor α axis

QQ Zhou, L Yang, ML Verne, BB Zhang, J Fields… - Gastroenterology, 2023 - Elsevier
… The COMT/catecholamine pathway has been studied for … However, we did not observe
a significant change in transit … Our results here show that anti-TNF therapy can silence miR-…

Catechol-O-methyltransferase gene (COMT) is associated with neurocognitive functioning in patients with sickle cell disease

AM Heitzer, SR Rashkin, A Trpchevska… - Current Research in …, 2024 - Elsevier
… age and sex differences across samples. There are notable structural and functional changes
in … These changes include declines in frontal dopamine signaling that differs across COMT …

The Influence of Genetic Polymorphic Variability of the Catechol-O-methyltransferase Gene in a Group of Patients with a Diagnosis of Behavioural Addiction, including …

R Recław, K Chmielowiec, A Suchanecka, A Boroń… - Genes, 2024 - mdpi.com
… , which is a postsynaptic enzyme that degrades catecholamines (epinephrine, dopamine
and … The psychiatric phenotypes affected by the COMT genotype exhibit sex-specificity [73], …

The association of catechol-O-methyltransferase genetic polymorphism rs4680 in physical activity among adult women

L Gotlieb, S Ben-Zaken - bioRxiv, 2022 - biorxiv.org
… The enzyme COMT degrades catecholamines, including dopamine. Two main COMT …
Further research is needed in order to explore the relations between sex hormonal changes

Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in …

J Chi, Y Ma, M Shi, C Lu, Q Jiang, Y Li, X Zhang, X Shi… - Brain Research, 2024 - Elsevier
… C allele at rs4818 SNP exhibited significantly better immediate memory and speech functions
compared to G allele carriers. However, our findings did not show any effect of the rs4680 …