Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

H Scholz, FJ Boivin, KM Schmidt-Ott… - Nature Reviews …, 2021 - nature.com
… of the nephron segments might contribute to the heterogeneous … This approach identified
the collecting duct as a major … regulated cell death 89 . Mitophagy is important for maintaining …

[HTML][HTML] Autophagy and inflammation regulation in acute kidney injury

L Gong, Q Pan, N Yang - Frontiers in physiology, 2020 - frontiersin.org
… (AKI), whereas abnormal autophagy may lead to cell death. … and renal tissue inflammation
in AKI may contribute to the … , ROS generation, and apoptosis in renal tubular cells, alongside …

[HTML][HTML] Ferroptosis and acute kidney injury (AKI): molecular mechanisms and therapeutic potentials

Q Feng, X Yu, Y Qiao, S Pan, R Wang… - Frontiers in …, 2022 - frontiersin.org
… Aside from its effects on cell death, autophagy, apoptosis, and pyroptosis, p53 is also …
In conclusion, p53 can not only regulate apoptosis and cell cycle arrest, but also inhibit the …

[HTML][HTML] PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cells

H Zhu, W Jiang, H Zhao, C He, X Tang, S Xu, C Xu… - Cell death & …, 2020 - nature.com
… Histone acetylation-mediated silencing of PSTPIP2 may contribute to cisplatin nephrotoxicity.
… This study provides a new perspective on the role of PSTPIP2 in AKI and identified a …

[HTML][HTML] The role of mitochondria in acute kidney injury and chronic kidney disease and its therapeutic potential

X Zhang, E Agborbesong, X Li - International journal of molecular …, 2021 - mdpi.com
… , oxidative stress, apoptosis, and eventually renal failure. It is … cell death, but also attenuated
progressive kidney injury and fibrosis … a novel approach to prevent or attenuate kidney injury. …

Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis

G Huang, J Bao, X Shao, W Zhou, B Wu, Z Ni, L Wang - Life sciences, 2020 - Elsevier
… be a potential approach in the clinical therapy of SI-AKI. … pathological processes including
cell death and inflammation. … Nevertheless, functional contributions of T lymphocytes cannot be …

[HTML][HTML] Targeting ferroptosis in acute kidney injury

L Ni, C Yuan, X Wu - Cell Death & Disease, 2022 - nature.com
cellular proteases contribute to the disintegration of skeletons, membranes, and proteins [30,31,32].
We also consider apoptosis … From a therapeutic point of view, pharmacological …

Melittin ameliorates endotoxin‐induced acute kidney injury by inhibiting inflammation, oxidative stress, and cell death in mice

JY Kim, J Leem, HL Hong - Oxidative medicine and cellular …, 2021 - Wiley Online Library
… promising therapeutic approach for … apoptosis and renal injury in endotoxin-induced renal
injury [39]. In this study, LPS-treated mice displayed a profound increase in number of cells

[HTML][HTML] Programmed cell death in diabetic nephropathy: a review of apoptosis, autophagy, and necroptosis

NS Erekat - Medical Science Monitor: International Medical Journal …, 2022 - ncbi.nlm.nih.gov
… tubular cells is increased in stress conditions, such as those caused by acute kidney injury
… Thus, a calorie restriction regimen must be regarded as an effective therapeutic approach to …

[HTML][HTML] Drug-induced acute kidney injury

MA Perazella, MH Rosner - … Journal of the American Society of …, 2022 - journals.lww.com
… Their excretory pathways through the proximal tubules contributeinjury with development
of cell apoptosis/necrosis (Figure 1) ( 19 ). Death and inflammation of proximal tubular cells as …