… regulator of HIF-α degradation and has a key role in HIF-α … has varied roles in regulating
their stability, activity, subcellular … Whilst this implies cell type specific aspects in the action of …

… tissues can be partially ascribed to cell type-specific differences in the chromatin landscape
… suggested a role for GCs in promoting c-src–mediated proteasomal degradation of pVHL …

… While Hypoxia-Inducible Factor (HIF)-1α has been shown to be … and targeted for proteasomal
degradation by E3 ubiquitin ligase … Subcellular fractionation from hypoxic J774 monocytes-…

… The Hypoxia Inducible Factor 1 (HIF-1) plays a major role in … a regulatory hub since it controls
the subcellular localization … that are often incomplete or cell-type specific. On the other hand…

… Regulation of HIF- 1 function is critically dependent on the degradation of the HIF- 1α …
Regulation of hypoxia- inducible factor 1 and the loss of the cellular response to hypoxia in …

… governed by stabilisation of hypoxia-inducible factors, principally the transcription factor …
levels will tend to block the HIF-1α degradation pathway, thus triggering the expression of HIF …

… by the transcription factor hypoxia-inducible factor-1 (HIF-1) … 1α is rapidly degraded in
normoxic conditions. When low O 2 concentration, as hypoxia occurs, PHDs are inactive, HIF-1α …

… transcription factors, namely the hypoxia inducible factors (… HIFs for eventual proteasomal
degradation. HIFs, as well as … tissues, have specific subcellular localization patterns, and …

… Here, we report distinct roles for hypoxia-inducible factor-1α (Hif-1α) in the regulation of BACE1
and γ-… , which would degrade all endogenous Hif-1α. Expression of viral constructs of Hif-…

… be regulated through the canonical hypoxia inducible factor (HIF) family of transcription factors…
in transcription, splicing, degradation, subcellular localisation, and translation 116. Further …