Alarmins as a Possible Target of Future Therapies for Atrial Fibrillation

E Imbalzano, G Murdaca, L Orlando… - … Journal of Molecular …, 2022 - mdpi.com
ectopic electrical pulses is able to start and sustain irregular electrical activity of atrial fibrillation
This study showed a linear correlation of HMGB1 with TF, myeloid differentiation factor 88 …

[HTML][HTML] Decoding the PITX2-controlled genetic network in atrial fibrillation

JD Steimle, FJG Canozo, M Park, ZA Kadow… - Jci Insight, 2022 - ncbi.nlm.nih.gov
… To do this, we contrasted the correlation matrices of motifs at all accessible chromatin sites
… these ectopic beats, various cell types have been identified in the PVs of human patients and …

[HTML][HTML] ROCK (RhoA/Rho kinase) activation in atrial fibrillation: molecular pathways and clinical implications

R Proietti, AS Giordani, CA Lorenzo - Current Cardiology Reviews, 2023 - ncbi.nlm.nih.gov
… Both EAD and DAD promote on the one side ectopic triggered activity of … arrhythmia in
dialysis ESRD patients that also presented increased MYPT-1phosphorylation, which correlated

Imaging techniques for the study of fibrosis in atrial fibrillation ablation: from molecular mechanisms to therapeutical perspectives

F De Sensi, D Penela, D Soto-Iglesias… - Journal of Clinical …, 2021 - mdpi.com
… , it is not possible to discern between ectopic (triggered) activity and/or re-entry. Furthermore…
Utah stage classification of left atrial fibrosis with cardiac MRI and correlation with outcomes …

Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care

J Heijman, H Sutanto, HJGM Crijns… - Cardiovascular …, 2021 - academic.oup.com
… levels, afterdepolarizations can induce focal ectopic firing, often arising from myocardial
sleeves around the pulmonary veins. Re-entrant activity initiated by ectopic activity acting on a …

Atrial Fibrillation and Diabetes Mellitus: Dangerous Liaisons or Innocent Bystanders?

A Lorenzo-Almoros, J Casado Cerrada… - Journal of Clinical …, 2023 - mdpi.com
… wavefronts that initiate a spontaneous premature ectopic activity [22]. The slowed conduction
… SGLT2i were also correlated with lower risk of AF, atrial flutter and sudden cardiac death in …

The role of phosphorylation in atrial fibrillation: a focus on mass spectrometry approaches

S Safabakhsh, P Panwar, S Barichello… - Cardiovascular …, 2022 - academic.oup.com
… In most studies, increased CaMKII activity is correlated with higher amounts of T287 …
mechanisms induced by atrial remodelling are key to allowing ectopic beats to form self-…

[HTML][HTML] Epicardial adipocytes in the pathogenesis of atrial fibrillation: An update on basic and translational studies

B Willar, KV Tran, TP Fitzgibbons - Frontiers in Endocrinology, 2023 - frontiersin.org
… cardiomyocytes, leading to reentry and ectopic activity. Fibrosis leads to progression from …
correlate with the development of atrial fibrillation and adverse outcomes after atrial fibrillation

MicroRNAs Regulate TASK‐1 and Are Linked to Myocardial Dilatation in Atrial Fibrillation

F Wiedmann, M Kraft, S Kallenberger… - Journal of the …, 2022 - Am Heart Assoc
correlation of microRNA levels in the atrium with clinical parameters may suggest that subtypes
of atrial fibrillation … an increased ectopic activity results in elevated susceptibility for AF. …

[HTML][HTML] Differential effects of class I antiarrhythmic drugs on the guinea pig pulmonary vein myocardium: Inhibition of automatic activity correlates with blockade of a …

M Irie, H Hiiro, S Kato, M Kuramochi… - Journal of …, 2020 - Elsevier
atrial fibrillation arising from pulmonary vein ectopy. At present, the effect of class I antiarrhythmic
drugs on the automatic activity … treatment of atrial fibrillation on the automatic activity of …