Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
… evidence relating basic electrophysiological mechanisms to … Analyses of cellular
electrophysiology in right-atrial samples … evidence that AF initiation involves atrial ectopic triggers …
electrophysiology in right-atrial samples … evidence that AF initiation involves atrial ectopic triggers …
[HTML][HTML] Molecular basis of atrial fibrillation initiation and maintenance
K Beneke, CE Molina - Hearts, 2021 - mdpi.com
… advances in molecular and cellular basis for AF initiation, maintenance and progression.
We first provide an overview of the basic molecular and electrophysiological mechanisms that …
We first provide an overview of the basic molecular and electrophysiological mechanisms that …
[HTML][HTML] Cellular and mitochondrial mechanisms of atrial fibrillation
… initiation and maintenance of AF. Ectopic activity describes abnormal impulse generation
outside the sino-atrial … at high frequencies, can maintain the arrhythmia as a so-called “driver”. …
outside the sino-atrial … at high frequencies, can maintain the arrhythmia as a so-called “driver”. …
[HTML][HTML] Molecular insights in atrial fibrillation pathogenesis and therapeutics: a narrative review
KA Papathanasiou, SG Giotaki, DA Vrachatis, G Siasos… - Diagnostics, 2021 - mdpi.com
… A frequency-domain approach, utilized to explain AF initiation and maintenance, … fibroblasts
affect cell-to-cell electrical coupling and exhibit altered electrophysiological properties in …
affect cell-to-cell electrical coupling and exhibit altered electrophysiological properties in …
[HTML][HTML] Multicellular In vitro Models of Cardiac Arrhythmias: Focus on Atrial Fibrillation
PRR Van Gorp, SA Trines, DA Pijnappels… - Frontiers in …, 2020 - frontiersin.org
… the initiation and maintenance of atrial arrhythmias, there are … and atrial CMs on a structural
and electrophysiological level (… small cell clusters to assess, electrophysiological parameters …
and electrophysiological level (… small cell clusters to assess, electrophysiological parameters …
Comprehensive evaluation of electrophysiological and 3D structural features of human atrial myocardium with insights on atrial fibrillation maintenance mechanisms
… The other half of the equation for wavelength of reentry, local APD/ERP, has been demonstrated
to be an important determinant of perAF initiation and maintenance. In general, clinical …
to be an important determinant of perAF initiation and maintenance. In general, clinical …
Linking cellular energy state to atrial fibrillation pathogenesis: potential role of adenosine monophosphate–activated protein kinase
P Chakraborty, S Nattel, K Nanthakumar - Heart rhythm, 2020 - Elsevier
… atrial fibrillation. AMPK activation is thought to be protective by preventing metabolic stress,
favorably modulating membrane electrophysiology … Maintenance cardiac active ion transport …
favorably modulating membrane electrophysiology … Maintenance cardiac active ion transport …
Pathophysiology and therapeutic relevance of PI3K (p110α) protein in atrial fibrillation: A non-interventional molecular therapy strategy
M Ezeani, S Prabhu - Pharmacological Research, 2021 - Elsevier
… of atrial tissue that can harbor re-entry circuits) and initiating proarrhythmic cellular and
molecular … The molecular determinants of atrial electrophysiology have been investigated [60,61]. …
molecular … The molecular determinants of atrial electrophysiology have been investigated [60,61]. …
[HTML][HTML] Inflammatory signalling in atrial cardiomyocytes: a novel unifying principle in atrial fibrillation pathophysiology
… antiarrhythmic drugs to promote maintenance of normal sinus … The cell swelling, cell
membrane disruption and release of … mediator of HF initiation and progression 104 , which is a …
membrane disruption and release of … mediator of HF initiation and progression 104 , which is a …
Atrial fibrosis as a dominant factor for the development of atrial fibrillation: facts and gaps
… between cellular and molecular mechanisms of atrial fibrosis … the electrophysiological
properties and the structure of atrial tissue. … Its action initiates by binding to its G protein-coupled …
properties and the structure of atrial tissue. … Its action initiates by binding to its G protein-coupled …