Kidney fibrosis: from mechanisms to therapeutic medicines

R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
… Furthermore, a better understanding of renal fibrosis is also favored to discover biomarkers
of fibrotic injury. In the review, we update recent advances in the mechanism of renal fibrosis

New insights into the role and mechanism of partial epithelial-mesenchymal transition in kidney fibrosis

L Sheng, S Zhuang - Frontiers in physiology, 2020 - frontiersin.org
… of renal fibrosis. Moreover, the cellular and molecular mechanisms mediating fibrosis are still
not … of the complex mechanisms and related cellular mediators of kidney fibrosis is urgently …

Cellular and molecular mechanisms underlying liver fibrosis regression

A Caligiuri, A Gentilini, M Pastore, S Gitto, F Marra - Cells, 2021 - mdpi.com
… In this review, we will discuss the major cellular and molecular mechanisms underlying the
regression of fibrosis/cirrhosis and the potential therapeutic approaches aimed at reversing …

The fibrogenic niche in kidney fibrosis: components and mechanisms

L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
… approach to identifying the mechanisms of kidney fibrosis. In this article, we review the
composition, function and mechanisms of action of the fibrogenic niche in kidney fibrosis. We also …

Fibrosis in chronic kidney disease: pathogenesis and consequences

S Panizo, L Martínez-Arias, C Alonso-Montes… - … journal of molecular …, 2021 - mdpi.com
… understand the common and distinct molecular mechanisms of fibrosis in different tissues
and … standing for kidney fibrosis, it progressively reduces the renal function, replacing within …

[HTML][HTML] Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

H Yan, J Xu, Z Xu, B Yang, P Luo, Q He - Biomedicine & Pharmacotherapy, 2021 - Elsevier
kidney residents and infiltrated cells during renal fibrosis, attempt to comprehensively discuss
the mechanism of renal fibrosis from the cellular … treatments for patients with renal fibrosis. …

Cellular and molecular mechanisms of kidney injury in 2, 8-dihydroxyadenine nephropathy

BM Klinkhammer, S Djudjaj, U Kunter… - Journal of the …, 2020 - journals.lww.com
… Rodent models of the cellular and molecular mechanisms of 2,8-DHA nephropathy and
crystal clearance have clinical relevance and offer insight into potential future targets for …

Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities

CC Gifford, J Tang, A Costello, NS Khakoo… - Clinical …, 2021 - portlandpress.com
… TGF-β1 ligand synthesis/secretion and SMAD3 phosphorylation are significantly up-regulated
in several forms of kidney fibrosis including those of diabetic, hypertensive, obstructive, …

Targeting fibrosis: Mechanisms and clinical trials

M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
… aberrant signals have achieved potent anti-fibrotic efficacy in clinical trials. In this review, …
fibrosis diseases, including liver fibrosis, kidney fibrosis, cardiac fibrosis, and pulmonary fibrosis

Signaling pathways involved in diabetic renal fibrosis

Y Zhang, D Jin, X Kang, R Zhou, Y Sun… - Frontiers in cell and …, 2021 - frontiersin.org
renal fibrosis and listed related clinical trials. The purpose of this review is to elucidate the
mechanisms and related pathways of renal fibrosis … to delay the progression of renal fibrosis. …