Cellular and mitochondrial mechanisms of atrial fibrillation
… The molecular mechanisms underlying atrial fibrillation (AF), the most common form of
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …
ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …
… In a proof-of-concept study in chronically instrumented conscious goats, transition from
paroxysmal atrial fibrillation (AF) to sustained AF due to chronic atrial pacing was documented (‘…
paroxysmal atrial fibrillation (AF) to sustained AF due to chronic atrial pacing was documented (‘…
Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy …
F Seibertz, T Rubio, R Springer, F Popp… - Cardiovascular …, 2023 - academic.oup.com
… Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology …
-associated remodelling of cellular electrophysiology can be simulated in human atrial-like …
-associated remodelling of cellular electrophysiology can be simulated in human atrial-like …
Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective
… Analyses of cellular electrophysiology in right-atrial samples from patients with pAF show
no AF-induced remodeling of AP or ion-current properties 29 ; however, left-atrial inward-…
no AF-induced remodeling of AP or ion-current properties 29 ; however, left-atrial inward-…
Fibrotic remodeling during persistent atrial fibrillation: In silico investigation of the role of calcium for human atrial myofibroblast electrophysiology
… to an atrial myocyte affects the action potential under electrical remodeling due to … atrial
fibrillation. We further hypothesize that such changes on the cellular level affect arrhythmia …
fibrillation. We further hypothesize that such changes on the cellular level affect arrhythmia …
Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes
P Lugenbiel, K Govorov, P Syren, AK Rahm… - Basic Research in …, 2021 - Springer
… Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular
electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key …
electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key …
Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution
… Electrophysiological mapping of chronic atrial fibrillation (AF) … ablation, but current
electrophysiological tools are limited by … ) array for complex electrophysiological signal recording …
electrophysiological tools are limited by … ) array for complex electrophysiological signal recording …
Linking cellular energy state to atrial fibrillation pathogenesis: potential role of adenosine monophosphate–activated protein kinase
P Chakraborty, S Nattel, K Nanthakumar - Heart rhythm, 2020 - Elsevier
… plays a crucial role in the pathogenesis of atrial fibrillation. AMPK activation is thought to be
… membrane electrophysiology including cytosolic Ca 2+ dynamics; preventing cellular growth; …
… membrane electrophysiology including cytosolic Ca 2+ dynamics; preventing cellular growth; …
Multicellular In vitro Models of Cardiac Arrhythmias: Focus on Atrial Fibrillation
PRR Van Gorp, SA Trines, DA Pijnappels… - Frontiers in …, 2020 - frontiersin.org
… These studies mostly involved the use of single cells or small cell clusters to assess,
electrophysiological parameters like AP morphology and duration, the properties of (individual) …
electrophysiological parameters like AP morphology and duration, the properties of (individual) …
The electrophysiology of atrial fibrillation: From basic mechanisms to catheter ablation
P Ioannidis, T Zografos, E Christoforatou… - Cardiology research …, 2021 - Wiley Online Library
… electrophysiology catheter that is in contact with the myocardium, the lipid bilayer of the cell
… Multiple microscopic pores are formed in the cell membrane, resulting in disturbance of cell …
… Multiple microscopic pores are formed in the cell membrane, resulting in disturbance of cell …
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