Cellular and mitochondrial mechanisms of atrial fibrillation

FE Mason, JRD Pronto, K Alhussini, C Maack… - Basic research in …, 2020 - Springer
… The molecular mechanisms underlying atrial fibrillation (AF), the most common form of
arrhythmia, are poorly understood and therefore target-specific treatment options remain an …

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology …

KE Odening, AM Gomez, D Dobrev, L Fabritz… - EP …, 2021 - academic.oup.com
… In a proof-of-concept study in chronically instrumented conscious goats, transition from
paroxysmal atrial fibrillation (AF) to sustained AF due to chronic atrial pacing was documented (‘…

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy …

F Seibertz, T Rubio, R Springer, F Popp… - Cardiovascular …, 2023 - academic.oup.com
Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology
-associated remodelling of cellular electrophysiology can be simulated in human atrial-like …

Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
… Analyses of cellular electrophysiology in right-atrial samples from patients with pAF show
no AF-induced remodeling of AP or ion-current properties 29 ; however, left-atrial inward-…

Fibrotic remodeling during persistent atrial fibrillation: In silico investigation of the role of calcium for human atrial myofibroblast electrophysiology

J Sánchez, B Trenor, J Saiz, O Dössel, A Loewe - Cells, 2021 - mdpi.com
… to an atrial myocyte affects the action potential under electrical remodeling due to … atrial
fibrillation. We further hypothesize that such changes on the cellular level affect arrhythmia

Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes

P Lugenbiel, K Govorov, P Syren, AK Rahm… - Basic Research in …, 2021 - Springer
Atrial fibrillation (AF) is associated with electrical remodeling, leading to cellular
electrophysiological dysfunction and arrhythmia perpetuation. Emerging evidence suggests a key …

Intrinsically stretchable electrode array enabled in vivo electrophysiological mapping of atrial fibrillation at cellular resolution

J Liu, X Zhang, Y Liu, M Rodrigo… - Proceedings of the …, 2020 - National Acad Sciences
Electrophysiological mapping of chronic atrial fibrillation (AF) … ablation, but current
electrophysiological tools are limited by … ) array for complex electrophysiological signal recording …

Linking cellular energy state to atrial fibrillation pathogenesis: potential role of adenosine monophosphate–activated protein kinase

P Chakraborty, S Nattel, K Nanthakumar - Heart rhythm, 2020 - Elsevier
… plays a crucial role in the pathogenesis of atrial fibrillation. AMPK activation is thought to be
… membrane electrophysiology including cytosolic Ca 2+ dynamics; preventing cellular growth; …

Multicellular In vitro Models of Cardiac Arrhythmias: Focus on Atrial Fibrillation

PRR Van Gorp, SA Trines, DA Pijnappels… - Frontiers in …, 2020 - frontiersin.org
… These studies mostly involved the use of single cells or small cell clusters to assess,
electrophysiological parameters like AP morphology and duration, the properties of (individual) …

The electrophysiology of atrial fibrillation: From basic mechanisms to catheter ablation

P Ioannidis, T Zografos, E Christoforatou… - Cardiology research …, 2021 - Wiley Online Library
electrophysiology catheter that is in contact with the myocardium, the lipid bilayer of the cell
… Multiple microscopic pores are formed in the cell membrane, resulting in disturbance of cell