HTLV-1 infection and pathogenesis: new insights from cellular and animal models

G Forlani, M Shallak, RS Accolla… - International Journal of …, 2021 - mdpi.com
… , which is typically associated only with HTLV-1 infection, … proteins in HTLV-1 infectivity
and pathogenicity. p8 and p12, … early steps of infection, at the entry step, the tropism is almost …

HIV-1 and HTLV-1 transmission modes: Mechanisms and importance for virus spread

S Kalinichenko, D Komkov, D Mazurov - Viruses, 2022 - mdpi.com
associated HTLV-1 viral particles fuse with the plasma membrane of target cells, or are
internalized and enter … whether this cellular model reflects the cell-to-cell transmission of HTLV-1, …

HTLV1 oncovirus‐host interactions: From entry to the manifestation of associated diseases

S Ahmadi Ghezeldasht, SAA Shamsian… - Reviews in medical …, 2021 - Wiley Online Library
HTLV-1 recruits many cellular and viral genes and form a protein ring in the … entry and
effective virus dissemination, and promote tissue damages involved in the HAM/TSP pathogenicity

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

S Ahmadi Ghezeldasht, DJ Blackbourn… - Critical Reviews in …, 2023 - Taylor & Francis
… cell entry to integrate into the host genome as the HTLV-1cellular factors involved in cell
survival and proliferation and malignancy. The HTLV-1-HBZ is a complicated regulatory factor

Identification of joint gene players implicated in the pathogenesis of HTLV-1 and BLV through a comprehensive system biology analysis

F Ashrafi, SA Ghezeldasht, MZ Ghobadi - Microbial pathogenesis, 2021 - Elsevier
… sets, hub genes, and modules in pathogenicity were screened. … Upon virus entry and
localization in host cells, subclinical … protein to mediate cellular transformation and metastasis in …

Extracellular vesicles from HTLV-1 infected cells modulate target cells and viral spread

DO Pinto, S Al Sharif, G Mensah, M Cowen, P Khatkar… - Retrovirology, 2021 - Springer
… efforts to understand HTLV-1 pathogenicity, more research is … examined whether HTLV-1
EVs alone are sufficient to enter (… the potential mechanisms of cellular damage, we sought to …

Extracellular vesicles in HTLV-1 communication: the story of an invisible messenger

S Al Sharif, DO Pinto, GA Mensah, F Dehbandi… - Viruses, 2020 - mdpi.com
… players involved are cell surface receptors and other cellular … The pathogenicity of HU is
characterized by a significant … -mediated endocytosis regulates HTLV-1 entry in immature DCs…

Co-Infection and Cancer: Host–Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses

TH Mulherkar, DJ Gómez, G Sandel, P Jain - Viruses, 2022 - mdpi.com
… by affecting cellular gag expression. Antiretroviral therapy (ART) is successful in controlling
HIV disease but has little effect on HTLV-1… of HTLV-1 immunopathogenesis through entry and …

Understanding the Immunopathology of HTLV-1-Associated Adult T-Cell Leukemia/Lymphoma: A Comprehensive Review

S Nakahata, D Enriquez-Vera, MI Jahan, K Sugata… - Biomolecules, 2023 - mdpi.com
… individuals is a determinant of HTLV-1 pathogenicity. As CD4+ T … to enter target cells. In
addition to CD4+ T cells, both HIV and … Its effects include antibody-dependent cellular cytotoxicity …

Functional properties and sequence variation of HTLV-1 p13

M Omsland, M Silic-Benussi, R Moles, S Sarkis… - Retrovirology, 2020 - Springer
… viral determinant of HTLV-1 pathogenicity have underscored the … The entry of K + increases
the activity of the electron … antiviral-signaling protein), a cellular protein localized in the outer …