[HTML][HTML] Protein kinases: drug targets for immunological disorders

L Castelo-Soccio, H Kim, M Gadina… - Nature Reviews …, 2023 - nature.com
… residues) as phosphate acceptors. Thus, protein … cell receptors (TCRs), B cell receptors
(BCRs), Fc receptors (FcRs) for IgG, natural killer (NK) cell receptors and C-type lectin receptors

Heteromerization between α1B‐adrenoceptor and chemokine (C‐C motif) receptor 2 biases α1B‐adrenoceptor signaling: Implications for vascular function

X Gao, AJ DeSantis, GA Enten, MW Weche… - FEBS …, 2022 - Wiley Online Library
… serves as the energy donor and energy acceptor, … the receptor and our findings on recombinant
receptors suggested β… hVSMCs to CCL2 and measured cell surface expression of CCR2 …

[HTML][HTML] Network pharmacology and molecular docking analysis of Catharanthus roseus compounds: Implications for non-small cell lung cancer treatment

G Alsaif, M Tasleem, R Rezgui, K Alshaghdali… - Journal of King Saud …, 2024 - Elsevier
The prevalence of non-small cell lung cancer (NSCLC), particularly in the Eastern Region of
Saudi Arabia, is concerning and highlights the need for novel treatments, despite recent …

[HTML][HTML] Metabolic implications of oxidative stress and inflammatory process in SARS-CoV-2 pathogenesis: therapeutic potential of natural antioxidants

GE Forcados, A Muhammad, OO Oladipo… - Frontiers in Cellular …, 2021 - frontiersin.org
… SARS-CoV-2 entry into a host cell involves a number of conformational changes requiring
binding of a virus particle to angiotensin-converting enzyme (ACE-2) receptor on the cell

[HTML][HTML] Small and large intestine (I): malabsorption of nutrients

MA Montoro-Huguet, B Belloc, M Domínguez-Cajal - Nutrients, 2021 - mdpi.com
… , as well as its clinical consequences, including both gastrointestinal symptoms … cell receptor
(TCR) and, in most cases, an unusual immunophenotype combining both T-cell and NK-cell

[HTML][HTML] Protective effect of CXCR4 antagonist CX807 in a rat model of hemorrhagic stroke

SJ Yu, KJ Wu, YS Wang, JS Song, CH Wu… - International Journal of …, 2020 - mdpi.com
… CX807 may have clinical implications for the treatment of hemorrhagic stroke. … The PathHunter
® β-Arrestin cell lines expressing chemokine receptors were used. The functional reporter …

The metabolic landscape of breast cancer and its therapeutic implications

Z Jiao, Y Pan, F Chen - Molecular Diagnosis & Therapy, 2023 - Springer
… as estrogen receptor (ER) and/or progesterone receptor (PR) … Afterward, THF, acting as a
1C acceptor, accepts serine derived … Moreover, the clinical consequences of ERβ regarding …

[HTML][HTML] Structural insights into ligand—receptor interactions involved in biased agonism of G-protein coupled receptors

K Jóźwiak, A Płazińska - Molecules, 2021 - mdpi.com
… of a given receptor, can produce qualitatively different cellular … and the fact might have clinical
consequences. On the other hand, … of a hydrogen bond acceptor substituent at the agonist …

[HTML][HTML] Activated PI3kinase delta syndrome—a multifaceted disease

R Thouenon, N Moreno-Corona, L Poggi… - Frontiers in …, 2021 - frontiersin.org
receptors, including T cell receptor/B cell receptor, cytokine … the splice donor or splice
acceptor sites of exon 11 leading to … in receptor tyrosine kinases and leads as a consequence to …

Hair cell α9α10 nicotinic acetylcholine receptor functional expression regulated by ligand binding and deafness gene products

S Gu, D Knowland, JA Matta… - Proceedings of the …, 2020 - National Acad Sciences
… This line (TMIE mutant) has a point mutation in the exon five splice acceptor site, which is …
in mammalian cells has important biochemical and biomedical implications. From a basic …