… in parsing CYP2D6 genotype-to-phenotype translation. This … in CYP2D6 and CYP2D7,
and thus present a challenge to … Analysis of large datasets is another approach to assign …

… phenotype, the assignment of CYP2D6 phenotype based on … value assigned to CYP2D6*10,
the first expert conference call … To address this challenge, recommendations from the CPIC …

… for accuracy of final genotype and phenotype assignment. Targeted … to difficulties in genotyping
and an overestimation of the … genotyped at the CYP2D6 locus, accurate star allele calls …

… auto-call method in the GT application module of Genotyping … [27] was used to infer the
gametic phase and to assign the … based on genotype test, we propose the use of “g-phenotype”, …

… phenomenon is called … challenges to implementing the use of CYP2D6 phenotype to guide
prescribing. These include proper interpretation of genotype-based phenotype from CYP2D6 …

… This article provides perspectives on these issues aiming to: (1) critically assess the assigned
… We have in this article critically highlighted the assigned enzyme activity scores of the …

… the relationship between CYP2D6 genotype and outcome of … of the difficulties associated
with phenotype definitions. For … were compared to calls from the Roche AmpliChip, which …

… Such problems range from a lack of efficacy to unanticipated … overlapping, which reflect
these assignments. It has been stated … of CYP2D6 activity levels based on the genotype are not …

… record calls for harmonization at the genotype and phenotype … exemplify particular challenges
of CYP2D6 nomenclature … alleles were genotyped or how phenotype was assigned. The …

… , but for some studies we had to assign an ethnicity to a country to … issues need to be addressed
in translating genotype data to … This phenomenon is called phenoconversion: it has been …