[HTML][HTML] Delivery of heterologous proteins, enzymes, and antigens via the bacterial type III secretion system

HA Pendergrass, AE May - Microorganisms, 2020 - mdpi.com
… The tip of the needle, or the translocon, forms a pore in the … the correct sequences in
characterization or screening assays… IpaB is an effector protein of Shigella that causes pyroptosis …

[HTML][HTML] Antibodies inhibiting the type III secretion system of Gram-negative pathogenic bacteria

JA Hotinger, AE May - Antibodies, 2020 - mdpi.com
… for Salmonella spp., Shigella spp., and E. coli including the needle tip, translocon, and secreted
… the needle tip from attaching to the translocon correctly or the translocon from integrating …

[HTML][HTML] Molecular targets and strategies for inhibition of the bacterial type III secretion system (T3SS); inhibitors directly binding to T3SS components

JA Hotinger, HA Pendergrass, AE May - Biomolecules, 2021 - mdpi.com
… the macromolecular T3SS in Shigella cells from cultures grown … SDS-PAGE analysis indicated
that secretion of YopE was … of the tip to the translocon, creating a translocation blockade […

Transcriptional and post-transcriptional regulatory mechanisms controlling type III secretion

M Volk, I Vollmer, AK Heroven, P Dersch - … Type III Protein Secretion …, 2020 - Springer
… with host cell contact/translocon-effector secretion. One of the … of two other type III secretion
machineries of Salmonella, the … enterocolitica was characterized by reduced secretion of the …

[PDF][PDF] Type III Secretion Systems (T3SSs), Structuring and Functions

SS Jaafar, EA AL-Hetty, HK Shareef - multiresearchjournal.com
… pathogenic Salmonella, Shigella, and Chlamydia species. … capable of secretion and membrane
translocation are effectively … functional characterization of the bacterial type III secretion

[HTML][HTML] Speaking the host language: how Salmonella effector proteins manipulate the host

TD Pillay, SU Hettiarachchi, J Gan… - …, 2023 - microbiologyresearch.org
… mediated by the Salmonella type III secretion system injectosome, … of numerous effectors
that remain poorly characterized. … (ii) After translocation they interact with host proteins; SteE …

[HTML][HTML] Comparative secretome analysis reveals cross-talk between type III secretion system and flagella assembly in Pseudomonas plecoglossicida

P Qin, Y Luan, J Yang, X Chen, T Wu, Y Li… - Heliyon, 2023 - cell.com
… and translocation nanomachines widely employed by many … The type III secretion system
needle tip complex mediates … ] showed that the translocon IpaB and IpaD proteins of Shigella

Systematic deletion of type III secretion system effectors in Enteropathogenic E. coli unveils the role of non-LEE effectors in a/E lesion formation

M Cepeda-Molero, S Schüller, G Frankel… - E. Coli Infections …, 2020 - books.google.com
… intestinal epithelial cells, characterized by the effacement of … (eg, Shigella , Yersinia ,
Salmonella ) to translocate virulence … –5 nm translocation pore, formed in the plasma membrane of …

Salmonella enterica serovar typhimurium exploits cycling through epithelial cells to colonize human and murine enteroids

P Geiser, ML Di Martino, P Samperio Ventayol… - MBio, 2021 - Am Soc Microbiol
type III secretion system 1 (TTSS-1) promoted Salmonella … by Salmonella Typhimurium SPI-1
mediates translocation of … had to be excluded from analysis at intermediate and high doses (…

[HTML][HTML] Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

S Ahmad, KK Tsang, K Sachar, D Quentin, TM Tashin… - Elife, 2020 - elifesciences.org
… (TMDs) implicated in effector translocation across target cell … proteins emerged from this
analysis: large prePAAR effectors … We previously demonstrated that the class II effector Tse6 …