… cruzain and BDF2 as key biological targets for the survival of the parasite. Our objective was
to identify potential inhibitors … the particular characteristics of each target (cruzain and BDF2) …

… characterization reveals a fast reversible mode of binding. In the second step, we explored
the effects on potency of cruzain … a covalent bond between the inhibitor and target. The latter …

… by revealing the need to target various cruzipain subtypes. … The analysis of available
complexes revealed a high frequency of … characteristics (eg, high energy conformations containing …

… Analysis of cruzain crystal structures reveals that the S3 to S1’ sub-pockets usually interact
… Another challenge in working with cruzain as a drug target is that it belongs to the cruzipain …

… The interest in CZP as a drug target has prompted the development of several types of … The
analysis of the intermolecular interactions in the crystal lattice reveals that the crystal structure …

… in screening assays using cruzain as the biological target. After this … Figure 4 shows selected
compounds from our data set. … However, this analysis focuses on the core structure of the …

… indices analysis (CoMSIA, r 2 pred = 0.73) revealed 3D … and is a validated molecular target
for Chagas disease drug … Trp184 was revealed to be highly relevant to cruzain inhibition. …

… , and explore cruzain and rhodesain as promising targets in … Also, in silico analysis at cruzain
revealed that compound (76… database revealed that 38 patents for cruzain inhibitors and 6 …

… used in covalent inhibitors targeting cruzain. Despite its … Inhibitor Bearing a Two-Step
Mechanism As the initial step to characterize the molecular mechanism of cruzain inhibition by …

… We highlight the proteins cruzain (CZ), … vitro assessment revealed a satisfactory balance
between CZ inhibition, in … Nevertheless, an analysis of the current drug candidates for CD shows …