… and Chemical Synthesis of Cm39 (α-KTx 4.8): A Scorpion Toxin That Inhibits Voltage-Gated K+ Channel KV1.2 and Small- and Intermediate-Conductance Ca2+-Activated K+ Channels K …

…, J Beltrán-Vidal, FZ Zamudio, K Shakeel… - Toxins, 2023 - mdpi.com
… experiments to reveal novel interactions with the vestibule of toxin-sensitive channels. … ,
ε-KTx, κ-KTx and λ-KTx [23]. α-KTxs are the most abundant toxins found in scorpion venom and …

… three-dimensional structure of the cationic peptide Stigmurin from Tityus stigmurus scorpion venom: In vitro antioxidant and in vivo antibacterial and healing activity

A Daniele-Silva, SCS Rodrigues, ECG Dos Santos… - Peptides, 2021 - Elsevier
structural information, allied with the multifunctional activity of Stigmurin, makes it an attractive
candidate for the design of novel … the structure-activity relationship of this bioactive peptide. …

Antimicrobial peptide analogs from scorpions: Modifications and structure-activity

B Amorim-Carmo, AMS Parente, ES Souza… - Frontiers in Molecular …, 2022 - frontiersin.org
… Thus, this review aims to address the AMPs found in scorpion venom and the most … activity
and modulate their toxicity to human cells, in addition to the possible application of scorpion

Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom

K Luna-Ramirez, A Csoti, JR McArthur… - Biochemical …, 2020 - Elsevier
… the basis for scorpion toxin classification, with six KTx subfamilies (α, β, γ, δ, κ, and λ) …
GFP-positive transfected cells were identified using a Nikon Eclipse TS-100 fluorescence …

Tityus serrulatus scorpion venom as a potential drug source for Chagas' disease: Trypanocidal and immunomodulatory activity

PM de Oliveira Pimentel, DRR de Assis… - Clinical …, 2021 - Elsevier
… The venom of the Brazilian yellow scorpion Tityus serrulatus (TsV) has been studied in …
structure-activity relationship studies showed that a tripeptide (KPP) was able to mimic the activity

Functional Characterization of a New Degradation Peptide BmTX4-P1 from Traditional Chinese Scorpion Medicinal Material

C Qin, X Yang, Y Zhang, G Deng, X Huang, Z Zuo… - Toxins, 2023 - mdpi.com
… the venom gland of traditional Chinese scorpion medicinal material. Considering the effective
medicinal value of the thermally processed scorpion venom … -P1 by chemical synthesis. …

[PDF][PDF] Scorpion Toxin-potassium Channel Interaction Law and its Applications

Z Zuo, Z Chen, Z Cao, W Li, Y Wu - neurotoxins, 2021 - researchgate.net
… amino acids in toxin κ-PVIIA, which make κ-PVIIA a typical polar molecule (Figs. 7A). Similar
to … Chemical synthesis and structure-activity relationships of Ts kappa, a novel scorpion toxin

[HTML][HTML] Exploring the potential of Brazilian Amazonian scorpion venoms: A comprehensive review of research from 2001 to 2021

JR da Cruz, P Bulet, CM de Moraes - Toxicon: X, 2023 - Elsevier
… beneficial properties of scorpion venom toxins and how they … an opportunity to uncover
novel bioactive compounds that … , while also developing novel technologies and therapies that …

Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications

R Guo, G Guo, A Wang, G Xu, R Lai, H Jin - Molecules, 2023 - mdpi.com
… compete with the classical scorpion κ toxin AaH II for … novel tool for investigating sodium
channel voltage sensors and holds the potential to elucidate the relationships between structure

Structural and functional studies of LaIT2, an antimicrobial and insecticidal peptide from Liocheles australasiae

M Tamura, C Tatsushiro, EH Morita, S Ohki - Toxicon, 2022 - Elsevier
… a peptide toxin isolated from the venom of the Yaeyama scorpion, … Design and synthesis of
novel antimicrobial peptides on the … defensin protein, and structure-activity relationship study …