Guanylyl cyclase 2C (GUCY2C) in gastrointestinal cancers: recent innovations and therapeutic potential

AA Entezari, AE Snook, SA Waldman - Expert opinion on …, 2021 - Taylor & Francis
… and cyclooxygenase-2 (COX-1 and COX-2)-dependent and independent mechanisms […
further studies to validate the use of PDE5 inhibitors in colorectal cancer chemoprevention. …

Dendrimer-mediated delivery of anticancer drugs for colon cancer treatment

DB Rai, K Medicherla, D Pooja, H Kulhari - Pharmaceutics, 2023 - mdpi.com
… of an ancient Indian spice known as Curcurma longa. Three main chemopreventive mechanisms
of CUR … Additionally, CUR induces apoptosis by inhibiting cyclooxygenase-2 (COX-2), …

Molecular mechanisms underlying chemopreventive potential of butein: Current trends and future perspectives

HS Tuli, R Joshi, D Aggarwal, G Kaur, J Kaur… - Chemico-Biological …, 2021 - Elsevier
… Over the recent few decades, butein as a purified compound … cancer, colon cancer, liver
cancer, bladder cancer, breast … and cyclin D1) and invasion (cyclooxygenase 2 (COX-2) and …

Astragaloside in cancer chemoprevention and therapy

Y Wang, Z Zhang, Z Cheng, W Xie, H Qin… - Chinese Medical …, 2023 - journals.lww.com
… MMP-2, MMP-7, and cyclooxygenase-2, all of which promote tumor angiogenesis. A …
chemoprevention may also be extended to other tumors such as gastric cancer and colon cancer

[HTML][HTML] Pleiotropic effects of the COX-2/PGE2 axis in the glioblastoma tumor microenvironment

PT Dean, SB Hooks - Frontiers in Oncology, 2023 - frontiersin.org
… Expression of cyclooxygenase-2 and epidermal growth factor receptor in primary and
recurrent glioblastoma multiforme. J Cancer Res Clin Oncol (2005) 131(10):653–61. doi: 10.1007/…

[HTML][HTML] Adenomatous polyposis coli in cancer and therapeutic implications

O Noe, L Filipiak, R Royfman, A Campbell, L Lin… - Oncology …, 2021 - ncbi.nlm.nih.gov
… of different pharmacological agents for colorectal cancer recognize the role of inflammation
in tumorigenesis. Cyclooxygenase-2 (COX-2), an enzyme in the arachidonic acid pathway …

Assessing the current state of lung cancer chemoprevention: a comprehensive overview

M Ashraf-Uz-Zaman, A Bhalerao, CM Mikelis, L Cucullo… - Cancers, 2020 - mdpi.com
… Another marker of carcinogenesis is cyclooxygenase-2 (COX-2); an inducible form of … lung,
prostate, and colorectal cancer was assessed [149]. Out of three cancers that were monitored, …

Design of new improved curcumin derivatives to multi-targets of cancer and inflammation

A Harikrishnan, S Khanna, V Veena - Current Drug Targets, 2021 - ingentaconnect.com
… in the chemoprevention of colorectal cancer. Int J Mol Sci 2013; 14(9): 17972-85. … inhibition
of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT29 human colon cancer

Permeability of Hypogymnia physodes Extract Component—Physodic Acid through the Blood–Brain Barrier as an Important Argument for Its Anticancer and …

E Studzińska-Sroka, A Majchrzak-Celińska, P Zalewski… - Cancers, 2021 - mdpi.com
… hyaluronidase and cyclooxygenase-2 (COX-2) inhibition. The … the canonical Wnt pathway
in colorectal cancer cells [26] and … Our study confirmed the anticancer, chemopreventive and …

Novel targeting strategies on signaling pathways of colorectal cancer

P Sabale, S Waghmare, L Potey, P Khedekar… - Colorectal Cancer, 2024 - Elsevier
Among the most lethal cancers in the world, the rate of colorectal cancer (CRC) increases as
on rise in the rate of incidence so the mortality rate also rises, which shows a serious effect …