ATP‐responsive smart hydrogel releasing immune adjuvant synchronized with repeated chemotherapy or radiotherapy to boost antitumor immunity
L Sun, F Shen, L Tian, H Tao, Z Xiong, J Xu… - Advanced …, 2021 - Wiley Online Library
… culture supernatant, we verified that the ATP release from CT26 cells … induce ATP release
from tumor cells in vivo. For this purpose, we intravenously (iv) injected OxPt into CT26-tumor-…
from tumor cells in vivo. For this purpose, we intravenously (iv) injected OxPt into CT26-tumor-…
[HTML][HTML] Extracellular ATP promotes breast cancer chemoresistance via HIF-1α signaling
H Yang, YH Geng, P Wang, HQ Zhang, WG Fang… - Cell Death & …, 2022 - nature.com
… the resistance of cancer cells against apoptosis. … of the ATP-HIF-1α signaling pathway, and
our in vivo mouse model showed increased drug sensitivity of cancer cells to chemotherapy. …
our in vivo mouse model showed increased drug sensitivity of cancer cells to chemotherapy. …
[HTML][HTML] High ATP production fuels cancer drug resistance and metastasis: implications for mitochondrial ATP depletion therapy
… chemotherapy, allowing them to be naturally-selected for survival, based on their high …
This diagram illustrates that ATP-depletion can be induced in cancer cells by employing FDA-…
This diagram illustrates that ATP-depletion can be induced in cancer cells by employing FDA-…
[HTML][HTML] Extracellular ATP: a feasible target for cancer therapy
V Vultaggio-Poma, AC Sarti, F Di Virgilio - Cells, 2020 - mdpi.com
… tumor cell lines [88,89]. Thus, non-lytic pathways for ATP release are expressed by both immune
and tumor cells… the antitumor effects promoted by chemotherapy-induced cell-death [107…
and tumor cells… the antitumor effects promoted by chemotherapy-induced cell-death [107…
Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling
H Yang, YH Geng, P Wang, H Yang, YT Zhou… - Oncogene, 2020 - nature.com
… ATP induced a robust up-regulation of SOX9 in most breast cancer cells, we wondered
whether ATP … invasion and metastasis, we wondered whether ATP could induce chemotherapy …
whether ATP … invasion and metastasis, we wondered whether ATP could induce chemotherapy …
Tumor-Specific ONOO– Nanogenerator for Improved Drug Delivery and Enhanced Chemotherapy of Tumor
Y Chen, ZH Li, P Pan, RY Zeng, XZ Zhang - ACS nano, 2021 - ACS Publications
… released from PMCS to induce tumor cell death. Interestingly, copper transporter 1 (CTR1),
which was down-regulated in tumor cells to decrease the cellular … cells, intracellular ATP …
which was down-regulated in tumor cells to decrease the cellular … cells, intracellular ATP …
[HTML][HTML] Chemotherapy resistance: Role of mitochondrial and autophagic components
E Bahar, SY Han, JY Kim, H Yoon - Cancers, 2022 - mdpi.com
… Apoptosis of cancer cells is a desirable result of chemotherapeutic treatment. Inducing … ,
metabolic activities depend mostly on mitochondrial OXPHOS to create ATP, while cancer cells …
metabolic activities depend mostly on mitochondrial OXPHOS to create ATP, while cancer cells …
Chemotherapeutic drug-induced immunogenic cell death for nanomedicine-based cancer chemo–immunotherapy
M Jiang, J Zeng, L Zhao, M Zhang, J Ma, X Guan… - Nanoscale, 2021 - pubs.rsc.org
… Therefore, by administrating these ICD-inducing chemotherapeutic drugs, tumor cells … ATP
from the dying tumor cells and caused immune stimulation. The ICD-associated ATP release …
from the dying tumor cells and caused immune stimulation. The ICD-associated ATP release …
ATP and cancer immunosurveillance
… ATP released by cancer cells succumbing to immunogenic cell death (ICD) not only mature
upon ATP‐driven inflammasome activation and migrate to tumor‐draining lymph nodes or …
upon ATP‐driven inflammasome activation and migrate to tumor‐draining lymph nodes or …
Reversing multidrug resistance by inducing mitochondrial dysfunction for enhanced chemo-photodynamic therapy in tumor
C Shi, H Huang, X Zhou, Z Zhang, H Ma… - … Applied Materials & …, 2021 - ACS Publications
… As expected, PDT-induced in situ mitochondrial dysfunction … ATP level, which aggrandized
intracellular drug concentration for amplifying therapeutic efficacy on MDR cancer cells. In …
intracellular drug concentration for amplifying therapeutic efficacy on MDR cancer cells. In …