… and immune disorders including autoimmune diseases, cancers… Cholesterol buildup in CD11c
+ MHCII + cells impairs antigen … cholesterol metabolism and the adaptive immune system. …

… factors have a major role in shaping the function of adaptive immune cells such as T and B
cells… Accumulated cholesterol in innate immune cells enhances NLRP3 inflammasome activity…

… , thereby increasing the risk of autoimmune diseases [21,22,… effect of CHB on cholesterol
metabolism in immune cells, we … in cholesterol levels and lipid raft formation on CD11c + DCs …

… lipid rafts to relavant targeted organs (113). … cholesterol-containing diet in ApoE/LXRβ-deficient
mice would result in lupus-like disease, and defects of LXRβ in CD11c+cells led to B-cell …

… This underlines the need to develop immune-targeted … a core region of activated immune
cells, cholesterol crystals and … aortic CD11c–YFP + antigen-presenting cells (APCs) and T cells …

… , immune dysfunction can be targeted by modifying cell … this cholesterol accumulation in
CD11c + cells, enhancing their capacity to present antigen and promoting autoimmune disease […

… -LDL, which causes cholesterol accumulation in the coronary … 25-HC promoted expression
of CD11c, a DC marker in bone … to a lack of a cause-and-effect relationship between ISP and …

… and ABCG1 accumulate intracellular cholesterol, which in … with immune cells and immune
responses. Lxrβ −/− T and B … of tumor-infiltrating CD11c + DCs and CD3 + T cells as compared …

… of immune cells, thereby contributing to disease development, like … cholesterol accumulation
in lymphoid organs promotes T cell … In this study, however, CD11c + cells were studied that …

… and circumstantial, rather than causal (7). However, the … proatherogenic immune cells, but
also influence cholesterol … of this cytokine by CD11c hi MHC-II + cells (conventional DC, cDC) …