Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory

G de Leo, R Gulino, M Coradazzi… - Brain …, 2023 - academic.oup.com
… Severe loss of cholinergic neurons in the basal forebrain nuclei and of noradrenergic …
and/or concurrent contribution to spatial learning and memory, known to be severely affected in …

Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

P Jarzebowski, CS Tang, O Paulsen, YA Hay - Elife, 2021 - elifesciences.org
… Functional expression of ChR2 in cholinergic neurons We aimed to investigate the effects
of cholinergic modulation on hippocampal oscillations and performance in a spatial navigation

Modulation of spatial memory and expression of hippocampal neurotransmitter receptors by selective lesion of medial septal cholinergic and GABAergic neurons

MG Dashniani, MA Burjanadze… - Experimental Brain …, 2020 - Springer
… of cholinergic or GABAergic SH projections and studied how they may differently … spatial
learning and memory and the expression of the following neurotransmitter receptors: cholinergic

[HTML][HTML] Learning from inhibition: Functional roles of hippocampal CA1 inhibition in spatial learning and memory

N Jeong, AC Singer - Current Opinion in Neurobiology, 2022 - Elsevier
… , exactly how interneurons affect local circuit computations during spatial navigationspatial
learning and memory and discuss open questions about CA1 interneurons in spatial learning

Inactivation of the striatum in aged rats rescues their ability to learn a hippocampus-sensitive spatial navigation task

RS Gardner, PE Gold, DL Korol - Neurobiology of Learning and Memory, 2020 - Elsevier
… across memory systems in age-related decline in spatial learning and memory and …
that treatments that modulate the relative contribution of different memory systems may lead …

Striatal cholinergic interneurons are required for contending strategy selection while solving spatial navigation problems

JP Beccaria, CAP Annan, E Keifman… - Journal of …, 2022 - Soc Neuroscience
cholinergic interneurons (SCINs) modulatenavigational tasks where a goal can be
independently achieved by adopting an allocentric or egocentric strategy. SCIN-depleted mice learn

Evaluation of the activity of choline acetyltransferase from different synaptosomal fractions at the distinct stages of spatial learning in the Morris water maze

ZI Storozheva, EI Zakharova… - Frontiers in Behavioral …, 2021 - frontiersin.org
cholinergic circuits play a crucial role in learning and memory… hippocampal cholinergic
systems in spatial learning needs … with performance of the spatial navigation task in the Morris …

Cholinergic suppression of sharp wave-ripples impairs hippocampus-dependent spatial memory

P Jarzebowski, CS Tang, O Paulsen, YA Hay - bioRxiv, 2020 - biorxiv.org
cholinergic modulation on hippocampal oscillations and performance in a spatial navigation
… that timely control of cholinergic modulation is crucial for spatial learning on a time scale of …

Age-related changes in medial septal cholinergic and GABAergic projection neurons and hippocampal neurotransmitter receptors: relationship with memory …

MA Burjanadze, MG Dashniani, RO Solomonia… - Experimental Brain …, 2022 - Springer
… The effect of aging on spatial learning and memory function assessed in the Morris water
maze test (Y—young-adult, MA/U—middle-aged-unimpaired, MA/I—middle-aged-impaired and …

Differential behavior-related activity of distinct hippocampal interneuron types during odor-associated spatial navigation

T Forro, T Klausberger - Neuron, 2023 - cell.com
… We recorded from the intermediate CA1 hippocampus of head-fixed mice exhibiting odor-to-place
memory associations during navigation in a virtual reality (VR). The presence of an …