… B cells can be activated by diverse factors, including Toll-like … In fact, TLR9 has a complex
dual regulatory mechanism in B cells… Furthermore, Tlr9 − / − B cells predominantly become IgG …

… Mature B cells express B cell antigen receptor (BCR), toll-like … to form IgM, which lead to
generation of surface IgM + B cells. … robustly than control B cells upon BCR engagement (25). …

… B cell-intrinsic Toll-like receptor (TLR) signaling synergizes with the BCR to induce and shape
antibody production, hallmarked by immunoglobulin … to particular chromatin modules (66). …

… endosomal Toll-like receptors (TLRs), Fc gamma receptors (… response to FcεR activation
induced by immunoglobulin E (IgE) … , a surface receptor that upon ligand engagement enhances …

… that B cell Toll-like receptor 4 (TLR4)–B cell receptor (BCR) (… or intracellular B cell Toll-like
receptor (TLR) engagement by … We also stimulated in vitro human naïve IgM + IgD + B cells …

… IgM on the cell surface (Igµ and Igδ double positive B cells)4, … produced by such a B cell from
IgM to IgG, IgA or IgE. SHM … histone modifying enzymes and trigger chromatin relaxation in …

… Here we describe a role for av integrins in regulating Toll-like receptor (TLR) signalling by
… Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors…

… SWI/SNF chromatin remodeling complex to regulate expres… and natural immunoglobulin
IgM antibody production … The direct activation of autoreactive B cells and enhanced IFN …

… These cells are uniformly IgM low and do not express high … , organelles, or pathogens via
formation of a characteristic double-… and atg5 to regulate Toll-like receptor signalling in B cells. …

… by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) … these cells as IgM high CD20
low/neg differentiated B cells. … We demonstrate that the simultaneous engagement of BCR by …