Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring
E Jabbour, H Kantarjian - American journal of hematology, 2020 - Wiley Online Library
Disease overview Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm with an
incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly
diagnosed cases of leukemia in adults. Diagnosis CML is characterized by a balanced
genetic translocation, t (9; 22)(q34; q11. 2), involving a fusion of the Abelson gene (ABL1)
from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome
22q11. 2. This rearrangement is known as the Philadelphia chromosome. The molecular …
incidence of 1‐2 cases per 100 000 adults. It accounts for approximately 15% of newly
diagnosed cases of leukemia in adults. Diagnosis CML is characterized by a balanced
genetic translocation, t (9; 22)(q34; q11. 2), involving a fusion of the Abelson gene (ABL1)
from chromosome 9q34 with the breakpoint cluster region (BCR) gene on chromosome
22q11. 2. This rearrangement is known as the Philadelphia chromosome. The molecular …
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring
E Jabbour, H Kantarjian - American journal of hematology, 2022 - Wiley Online Library
Abstract Disease Overview Chronic Myeloid Leukemia (CML) is a myeloproliferative
neoplasm with an incidence of 1–2 cases per 100 000 adults. It accounts for approximately
15% of newly diagnosed cases of leukemia in adults. Diagnosis CML is characterized by a
balanced genetic translocation, t (9; 22)(q34; q11. 2), involving a fusion of the Abelson gene
(ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on
chromosome 22q11. 2. This rearrangement is known as the Philadelphia chromosome. The …
neoplasm with an incidence of 1–2 cases per 100 000 adults. It accounts for approximately
15% of newly diagnosed cases of leukemia in adults. Diagnosis CML is characterized by a
balanced genetic translocation, t (9; 22)(q34; q11. 2), involving a fusion of the Abelson gene
(ABL1) from chromosome 9q34 with the breakpoint cluster region (BCR) gene on
chromosome 22q11. 2. This rearrangement is known as the Philadelphia chromosome. The …
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