Mitochondrial and nuclear DNA oxidative damage in physiological and pathological aging

M Kowalska, T Piekut, M Prendecki, A Sodel… - DNA and cell …, 2020 - liebertpub.com
… of ROS associated with mitochondrial dysfunction amount to a “… and mitochondrial dysfunction.
Therefore, overproduction of ROS and mitochondrial abnormalities, together with chronic

Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D

N de Las Heras, VM Martín Giménez, L Ferder… - Antioxidants, 2020 - mdpi.com
… In fact, the leukemia virus infection on fibroblasts resulted in a … of cardiac dysfunction induced
by chronic immobilization … a pro-oxidative state associated with mitochondrial dysfunction […

Mitochondria and cellular redox state on the route from ageing to Alzheimer's disease

G Abate, M Vezzoli, M Sandri… - Mechanisms of Ageing …, 2020 - Elsevier
chronic age-related diseases, including neurodegenerative … environment to one with a
pro-oxidative profile would result in … described mitochondrial dysfunction as a prominent and early …

[PDF][PDF] Mitochondrial dysfunction and biological therapy: a new look at rheumatoid arthritis

T Kostova, V Mihaylova, R Karalilova… - Rheumatology …, 2022 - researchgate.net
… are associated with more pronounced hypoxia in the joint [9]. … and mitochondrial proteins
reflect mitochondrial dysfunctionsevere and prolonged inflammation in the joints of mice [13]. …

Mitochondrial dysfunction in lung ageing and disease

SM Cloonan, K Kim, P Esteves, T Trian… - European Respiratory …, 2020 - Eur Respiratory Soc
… become dysfunctional with ageing and in acute and chronic lung … This leads to chronic
bacterial airway infection, prominent … repressed in IPF fibroblasts and in fibroblasts isolated from …

Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart

D Bou-Teen, N Kaludercic, D Weissman… - Free Radical Biology …, 2021 - Elsevier
… and increased pro-oxidative status, largely involve mitochondria and … pathways in cardiac
fibroblasts and modulate matrix … the role of chronic ROS exposure and mitochondrial ROS in …

Proteomic profiling reveals mitochondrial alterations in Rett syndrome

V Cicaloni, A Pecorelli, L Tinti, M Rossi… - Free Radical Biology …, 2020 - Elsevier
… While the imbalance toward a pro-oxidative state is … model, ie primary dermal fibroblasts,
and a proteomic data … energy demand arising from a chronic oxinflammatory status [18]. Unlike …

Mitochondria in skin health, aging, and disease

A Sreedhar, L Aguilera-Aguirre, KK Singh - Cell death & disease, 2020 - nature.com
Chronic UV exposure induces nuclear and mitochondrial DNA … damage since melanogenesis
is pro-oxidative and have higher … and mitochondrial dysfunction seen in dermal fibroblasts

Mitochondrial dysfunction increases arrhythmic triggers and substrates; potential anti-arrhythmic pharmacological targets

K Saadeh, IT Fazmin - Frontiers in Cardiovascular Medicine, 2021 - frontiersin.org
… )-β which induce fibroblast production of matrix proteins and … content characterized by severe
hypertrophy and fibrosis (182)… and ROS generation, downregulated pro-oxidative pathways…

Mitochondrial dysfunction as a causative factor in Alzheimer's disease-spectrum disorders: lymphocytes as a window to the brain

M Jörg, JE Plehn, K Friedland… - Current Alzheimer …, 2021 - ingentaconnect.com
… accessible peripheral tissues like fibroblasts and blood cells [… more affected by aging, including
more severe mitochondrial … whey protein, can inactivate pro-oxidative proteins related to …