[HTML][HTML] Preclinical and clinical progress for HDAC as a putative target for epigenetic remodeling and functionality of immune cells

S Zhang, L Zhan, X Li, Z Yang, Y Luo… - International journal of …, 2021 - ncbi.nlm.nih.gov
… residues, thus promoting DNA condensation, and therefore, … decreased the production of
proinflammatory cytokines 86 . … Hodgkin lymphoma cells induces expression of OX40 ligand, …

[HTML][HTML] Comprehensive analysis of key genes, signaling pathways and miRNAs in human knee osteoarthritis: based on bioinformatics

L Chang, H Yao, Z Yao, KKW Ho, MTY Ong… - Frontiers in …, 2021 - frontiersin.org
genes and all of them were upregulated. Enrichment analysis showed that Module three
was enriched in “Wnt-protein … Pink line, interaction between key gene and key miRNA which …

Mitogen-and stress-activated protein kinase (MSK1/2) regulated gene expression in normal and disease states

H Sattarifard, A Safaei, E Khazeeva… - … and Cell Biology, 2023 - cdnsciencepub.com
… mutated genes in lung cancer, induces the expression of ETS … stimulated human primary
cultured fibroblast-like synoviocytes… increased production of pro-inflammatory cytokines leading …

Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

S Zhang, Y Meng, L Zhou, L Qiu, H Wang, D Su… - MedComm, 2022 - Wiley Online Library
… histones, resulting in the condensation of chromatin and the … further induces the expression
of proinflammatory cytokines and … METTL3 triggers fibroblast-like synoviocyte activation and …

[HTML][HTML] Modifiable risk factors linked to the development of rheumatoid arthritis: evidence, immunological mechanisms and prevention

JA Maisha, HS El-Gabalawy, LJ O'Neil - Frontiers in Immunology, 2023 - frontiersin.org
… actives local epithelial cells to produce pro-inflammatory cytokines (59), which enhances … ,
the addition of cigarette smoking and genetic risk to occupational exposures increases the risk …

[HTML][HTML] The anticarcinogenic effect of eugenol on lung cancer induced by diethylnitrosamine/2-acetylaminofluorene in Wistar rats: Insight on the mechanisms of action

HM Morsy, OM Ahmed, KMA Zoheir, A Abdel-Moneim - Apoptosis, 2023 - Springer
… by lower levels of proinflammatory cytokines and inflammation … showed a significant
upregulation of the expression of Bcl-2 … activated by the Bax gene, which increases cell cycle …

Glycolysis and beyond in glucose metabolism: exploring pulmonary fibrosis at the metabolic crossroads

Y Wang, X Wang, C Du, Z Wang, J Wang… - Frontiers in …, 2024 - frontiersin.org
… The AGEsRAGE axis induces upregulation of cytokines such … extent, inhibit the production
of pro-inflammatory cytokines (119). … and apoptosis of fibroblast-like synoviocytes by inhibiting …

TNF gene promoter DNA methylation level in early rheumatoid arthritis

TJ Sargent - 2023 - etheses.whiterose.ac.uk
… triggers including smoking and periodontal disease, which increases the … proinflammatory
cytokines, such as IL6, IL17 and TNFα, which engage fibroblasts, fibroblast-like synoviocytes

[HTML][HTML] Epigenetic regulation of inflammation in periodontitis: cellular mechanisms and therapeutic potential

KT Jurdziński, J Potempa, AM Grabiec - Clinical epigenetics, 2020 - Springer
… or Treponema denticola induces alterations in expression and … It typically causes
chromatin condensation and disruption of … in gingival fibroblasts and the GEC line TIGK (telomerase-…

[HTML][HTML] The emerging potential of siRNA nanotherapeutics in treatment of arthritis

A Kumari, A Kaur, G Aggarwal - Asian Journal of Pharmaceutical Sciences, 2023 - Elsevier
… In vivo studies have shown that this conjugate increases RNAi … stimulate the production of
pro-inflammatory cytokines and … cytokine level (TNF-α, IL-6 and IL-12) in synoviocytes as well …