… of activation … the cleavage activation mechanisms of coronavirus S proteins is described
with a focus on the newly emerged coronavirus, severe acute respiratory syndrome coronavirus …

… Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of …
to all major classes of proteolytic enzymes known to potentially activate coronavirus S proteins. …

… the functional and molecular requirements of spike activation. Through analyzing the prefusion
and postfusion spike protein products, we show that proteolytic cleavage at the S2′ site …

… believed that the severe acute respiratory syndrome coronavirus 2 (… respiratory syndrome
coronavirus spike protein (MERS-S) is activated by a two-step process: MERS-S is first cleaved …

… Recently, the International Committee on Taxonomy of Viruses (ICTV) has suggested to
name this virus as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on its …

… cleavage site similar to furin and this site is known to be cleaved during virus activation (24). …
TMPRSS2 initiates cleavage followed by activation of spike protein that promotes …

… to the emergence of a new type of coronavirus (CoV) called as severe acute respiratory …
respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein. …

… The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
… the important role of CTSL cleavage in the activation of S protein. To verify these observations…

… and activate the receptor-attached spike-like, S proteins [15]. … Other nonstructural proteins
from coronavirus that also have … functional proteins, macrodomains and PLpro (cleavage of …

… severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S) protein to
… However, for cathepsin L activation, S1/S2 cleavage is not required, and our results indicate …